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Untranslated Gene Regions and Other Non-coding Elements [electronic resource] : Regulation of Eukaryotic Gene Expression / by Lucy W. Barrett, Sue Fletcher, Steve D. Wilton.

By: Barrett, Lucy W [author.].
Contributor(s): Fletcher, Sue [author.] | Wilton, Steve D [author.] | SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: SpringerBriefs in Biochemistry and Molecular Biology: Publisher: Basel : Springer Basel : Imprint: Springer, 2013Description: VIII, 56 p. 2 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783034806794.Subject(s): Life sciences | Medical genetics | Nucleic acids | Plant breeding | Animal genetics | Life Sciences | Animal Genetics and Genomics | Plant Genetics & Genomics | Gene Function | Nucleic Acid ChemistryDDC classification: 591.35 Online resources: Click here to access online
Contents:
Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion.
In: Springer eBooksSummary: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
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Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion.

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.

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