Barrett, Lucy W.
Untranslated Gene Regions and Other Non-coding Elements Regulation of Eukaryotic Gene Expression / [electronic resource] : by Lucy W. Barrett, Sue Fletcher, Steve D. Wilton. - VIII, 56 p. 2 illus. in color. online resource. - SpringerBriefs in Biochemistry and Molecular Biology, 2211-9353 . - SpringerBriefs in Biochemistry and Molecular Biology, .
Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion.
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
9783034806794
10.1007/978-3-0348-0679-4 doi
Life sciences.
Medical genetics.
Nucleic acids.
Plant breeding.
Animal genetics.
Life Sciences.
Animal Genetics and Genomics.
Plant Genetics & Genomics.
Gene Function.
Nucleic Acid Chemistry.
QH432
591.35
Untranslated Gene Regions and Other Non-coding Elements Regulation of Eukaryotic Gene Expression / [electronic resource] : by Lucy W. Barrett, Sue Fletcher, Steve D. Wilton. - VIII, 56 p. 2 illus. in color. online resource. - SpringerBriefs in Biochemistry and Molecular Biology, 2211-9353 . - SpringerBriefs in Biochemistry and Molecular Biology, .
Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion.
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
9783034806794
10.1007/978-3-0348-0679-4 doi
Life sciences.
Medical genetics.
Nucleic acids.
Plant breeding.
Animal genetics.
Life Sciences.
Animal Genetics and Genomics.
Plant Genetics & Genomics.
Gene Function.
Nucleic Acid Chemistry.
QH432
591.35