Thymic Development and Selection of T Lymphocytes [electronic resource] / edited by Thomas Boehm, Yousuke Takahama.
By: Boehm, Thomas [editor.].
Contributor(s): Takahama, Yousuke [editor.] | SpringerLink (Online service).
Material type:
BookSeries: Current Topics in Microbiology and Immunology: 373Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014Description: VII, 132 p. 11 illus., 9 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783642402524.Subject(s): Medicine | Human genetics | Human physiology | Immunology | Biomedicine | Immunology | Human Physiology | CytogeneticsDDC classification: 616.079 Online resources: Click here to access online Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
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