Boehm, Thomas.
Thymic Development and Selection of T Lymphocytes [electronic resource] / edited by Thomas Boehm, Yousuke Takahama. - VII, 132 p. 11 illus., 9 illus. in color. online resource. - Current Topics in Microbiology and Immunology, 373 0070-217X ; . - Current Topics in Microbiology and Immunology, 373 .
Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
9783642402524
10.1007/978-3-642-40252-4 doi
Medicine.
Human genetics.
Human physiology.
Immunology.
Biomedicine.
Immunology.
Human Physiology.
Cytogenetics.
QR180-189.5
616.079
Thymic Development and Selection of T Lymphocytes [electronic resource] / edited by Thomas Boehm, Yousuke Takahama. - VII, 132 p. 11 illus., 9 illus. in color. online resource. - Current Topics in Microbiology and Immunology, 373 0070-217X ; . - Current Topics in Microbiology and Immunology, 373 .
Development and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
9783642402524
10.1007/978-3-642-40252-4 doi
Medicine.
Human genetics.
Human physiology.
Immunology.
Biomedicine.
Immunology.
Human Physiology.
Cytogenetics.
QR180-189.5
616.079