Library Services | Technical University of Kenya

Your cart is empty.
Normal view MARC view ISBD view

Polyploidization and Cancer [electronic resource] / edited by Randy Y. C. Poon.

By: Poon, Randy Y. C [editor.].
Contributor(s): SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Advances in Experimental Medicine and Biology: 676Publisher: New York, NY : Springer New York, 2010Description: XVI, 148p. 36 illus., 1 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9781441961990.Subject(s): Medicine | Biomedicine | Biomedicine generalDDC classification: 610 Online resources: Click here to access online
Contents:
Polyploidy, Aneuploidy and the Evolution of Cancer -- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability -- Understanding Cytokinesis Failure -- DNA Damage and Polyploidization -- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization -- Centrosomes, Polyploidy and Cancer -- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells -- Polyploidization of liver cells -- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry.
In: Springer eBooksSummary: Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.
Tags from this library: No tags from this library for this title. Log in to add tags.
No physical items for this record

Polyploidy, Aneuploidy and the Evolution of Cancer -- Molecular Mechanisms and Function of the Spindle Checkpoint, a Guardian of the Chromosome Stability -- Understanding Cytokinesis Failure -- DNA Damage and Polyploidization -- Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization -- Centrosomes, Polyploidy and Cancer -- Polyploidy: Mechanisms and Cancer Promotion in Hematopoietic and Other Cells -- Polyploidization of liver cells -- Analysis of Cellular DNA Content by Flow and Laser Scanning Cytometry.

Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.

There are no comments for this item.

Log in to your account to post a comment.

2017 | The Technical University of Kenya Library | +254(020) 2219929, 3341639, 3343672 | library@tukenya.ac.ke | Haile Selassie Avenue