000 05039nam a22005055i 4500
001 978-94-007-6621-1
003 DE-He213
005 20140220082943.0
007 cr nn 008mamaa
008 130522s2013 ne | s |||| 0|eng d
020 _a9789400766211
_9978-94-007-6621-1
024 7 _a10.1007/978-94-007-6621-1
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aHime, Gary.
_eeditor.
245 1 0 _aTranscriptional and Translational Regulation of Stem Cells
_h[electronic resource] /
_cedited by Gary Hime, Helen Abud.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aX, 371 p. 61 illus., 53 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v786
505 0 _aThe stem cell state -- Induction of pluripotency -- Germline stem cells and their regulation in the nematode Caenorhabditis elegans -- Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny -- Stem cells in the Drosophila digestive system -- Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System -- Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells -- Transcriptional Regulation and Specification of Neural Stem Cells -- Transcriptional Control of Epidermal Stem Cells -- Regulation of intestinal stem cells by Wnt and Notch signalling -- Transcriptional regulation of haematopoietic stem cells -- Regulation of mesenchymal stem cell differentiation -- Molecular families implicated in stem cell regulation -- The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations -- JAK-STAT signalling in stem cells -- Myc in Stem Cell Behaviour: insights from Drosophila -- The Role of Nuclear Receptors in Embryonic Stem Cells -- Epigenetic regulation of stem cells.- Regulation of stem cell populations by microRNAs -- Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches.
520 _aStem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury.  In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced.  Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of  differentiation could disrupt tissue homeostasis or  repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and  Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators. This volume will provide access to the current state of research in these rapidly evolving areas of stem cell biology to the student, educator or researcher.
650 0 _aMedicine.
650 0 _aCytology.
650 0 _aStem cells.
650 0 _aDevelopmental biology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aStem Cells.
650 2 4 _aCell Biology.
650 2 4 _aDevelopmental Biology.
700 1 _aAbud, Helen.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400766204
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v786
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-6621-1
912 _aZDB-2-SBL
999 _c99936
_d99936