000			03149nam a22004815i 4500
001			978-94-007-6570-2
003			DE-He213
005			20140220082943.0
007			cr nn 008mamaa
008			130605s2013 ne | s |||| 0|eng d
020			_a9789400765702 _9978-94-007-6570-2
024	7		_a10.1007/978-94-007-6570-2 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aCorso, Giovanni. _eeditor.
245	1	0	_aSpotlight on Familial and Hereditary Gastric Cancer _h[electronic resource] / _cedited by Giovanni Corso, Franco Roviello.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aXVIII, 211 p. 64 illus., 58 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aForeword -- Preface.-I General Issues -- Historical overview of familial gastric cancer -- Frequency of familial gastric cancer -- The family cancer database.- II Genetics and Epigenetics -- CDH1 gene, structure and function -- E-cadherin germline mutation -- Molecular mechanisms of hereditary diffuse gastric cancer initiation and progression -- Germline missense mutants in hereditary diffuse gastric cancer -- Alternative mechanisms to germline CDH1 mutations in hereditary diffuse gastric cancer -- Beyond CDH1 mutation-causes of hereditary gastric cancer -- Non-CDH1-associated familial gastric cancer and epigenetics factors.-III Pathology -- Hereditary diffuse gastric cancer and lobular breast carcinoma -- Pathology of hereditary diffuse gastric cancer.-IV Management -- Clinical criteria for familial gastric cancer definition -- Prophylactic total gastrectomy in CDH1 germline mutation carrier -- Gastric cancer in other inherited syndromes -- Clinical management of familial gastric cancer.- Appendix.- Index.
520			_aIn this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aHuman genetics.
650		0	_aGastroenterology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aBiomedicine general.
650	2	4	_aGastroenterology.
650	2	4	_aHuman Genetics.
700	1		_aRoviello, Franco. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400765696
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-6570-2
912			_aZDB-2-SBL
999			_c99923 _d99923