000			03208nam a22005175i 4500
001			978-94-007-6028-8
003			DE-He213
005			20140220082940.0
007			cr nn 008mamaa
008			130228s2013 ne | s |||| 0|eng d
020			_a9789400760288 _9978-94-007-6028-8
024	7		_a10.1007/978-94-007-6028-8 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aMartin, Tracey A. _eeditor.
245	1	0	_aTight Junctions in Cancer Metastasis _h[electronic resource] / _cedited by Tracey A. Martin, Wen G. Jiang.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aVIII, 313 p. 46 illus., 40 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Metastasis - Biology and Treatment, _x1568-2102 ; _v19
505	0		_aPreface -- The molecular aspects of Tight junctions -- The distribution of tight junctions and junctional proteins in the body -- Methodologies in investigation tight junctions -- Vascular permeability and drug delivery -- Tight junctions, BBB and brain metastasis -- Tight junctions and bladder cancer metastasis -- Tight Junctions and colorectal cancer therapies -- Tight junctions in breast cancer -- Regulation of tight junctions for therapeutic advantages -- Overcoming tight junctional permeability in cerebral metastasis -- CL-5 and cancer metastasis -- Intracellular signalling in TJ and AJ -- ROCK and TJ -- Index.
520			_aThere has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aCytology.
650		0	_aCell membranes.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aCancer Research.
650	2	4	_aOncology.
650	2	4	_aCell Biology.
650	2	4	_aMembrane Biology.
700	1		_aJiang, Wen G. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400760271
830		0	_aCancer Metastasis - Biology and Treatment, _x1568-2102 ; _v19
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-6028-8
912			_aZDB-2-SBL
999			_c99790 _d99790