000			03877nam a22005535i 4500
001			978-94-007-5590-1
003			DE-He213
005			20140220082938.0
007			cr nn 008mamaa
008			130202s2013 ne | s |||| 0|eng d
020			_a9789400755901 _9978-94-007-5590-1
024	7		_a10.1007/978-94-007-5590-1 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aSchmitz, Ulf. _eeditor.
245	1	0	_aMicroRNA Cancer Regulation _h[electronic resource] : _bAdvanced Concepts, Bioinformatics and Systems Biology Tools / _cedited by Ulf Schmitz, Olaf Wolkenhauer, Julio Vera.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aXII, 346 p. 93 illus., 70 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v774
505	0		_aPreface -- 1 MicroRNAs in human cancer -- 2 Bioinformatics, non-coding RNAs and its possible application in personalized medicine -- 3 MicroRNA target prediction and validation -- 4 MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology -- 5 The p53/microRNA network in cancer: experimental and bioinformatics approaches.-6 MicroRNAs in melanoma biology -- 7 MicroRNA in the lung -- 8 The E2F1-miRNA cancer progression network -- 9 Modeling of microRNA-transcription factor networks in cancer -- 10 Coordinated networks of microRNAs and transcription factors with evolutionary perspectives -- 11 Mathematical modeling of microRNA-mediated mechanisms of translation repression -- 12 Web resources for microRNA research -- 13 Discovery of microRNA regulatory networks by integrating multidimensional high-throughput data -- 14 Discovering the functional microRNA-mRNA regulatory modules in heterogeneous data -- 15 Elucidating the role of microRNAs in cancer through data mining techniques -- 16 Working together: Combinatorial regulation by microRNAs.  .
520			_aThis book reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and their applications in combination with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. The use of high-throughput quantitative techniques makes an integrative experimental and computational approach necessary. This book will be a resource for researchers starting out with microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology, and the state-of-the-art in computational microRNA biology.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aGene expression.
650		0	_aBioinformatics.
650		0	_aBiological models.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aBioinformatics.
650	2	4	_aComputational Biology/Bioinformatics.
650	2	4	_aSystems Biology.
650	2	4	_aMolecular Medicine.
650	2	4	_aGene Expression.
700	1		_aWolkenhauer, Olaf. _eeditor.
700	1		_aVera, Julio. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400755895
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v774
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-5590-1
912			_aZDB-2-SBL
999			_c99660 _d99660