000			03309nam a22004575i 4500
001			978-94-007-4716-6
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005			20140220082934.0
007			cr nn 008mamaa
008			120731s2013 ne | s |||| 0|eng d
020			_a9789400747166 _9978-94-007-4716-6
024	7		_a10.1007/978-94-007-4716-6 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aSeidler, Norbert W. _eauthor.
245	1	0	_aGAPDH: Biological Properties and Diversity _h[electronic resource] / _cby Norbert W. Seidler.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aXIV, 295 p. 96 illus., 8 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v985
520			_aGAPDH (glyceraldehyde 3-phosphate dehydrogenase) is more than just a glycolytic enzyme. An unprecedented amount of literature demonstrates that GAPDH has an astounding multiplicity of function. This diversity is not simply due to cell compartmentation (i.e. redistributing glycolytic energy to where it is needed), although this feature is undoubtedly important and discussed in the book. GAPDH integrates glycolysis with other cellular processes. This concept of integration cannot be understated. But, there is more. GAPDH actively participates in numerous non-glycolytic cellular events that fall into very broad categories including the cell infrastructure and the transmission of genetic information. Some of GAPDH’s biological properties are completely non-intuitive given the current undergraduate textbook understanding of this glycolytic enzyme. For example, GAPDH binds to select phospholipids and catalyzes organelle biogenesis. It has fusogenic properties, enabling it to be actively involved in nuclear envelop reassembly, autophagy and membrane trafficking. Human macrophages exhibit surface-localized GAPDH with receptor function. As scientists, we are trained to consider GAPDH as a soluble cytosolic dehydrogenase enzyme. The literature observations - as described in this book - tell us something quite different. Besides oxidoreductase activity, GAPDH exhibits peroxidase, uracil DNA glycosylase, nitrosylase, mono-ADP-ribosylase, esterase and phosphotransferase activity. GAPDH binds membrane transport proteins, G-proteins, poly-nucleotides, adenines, specific lipids, select carbohydrates, cytoskeletal proteins, nuclear import and export proteins, diverse ATPases, molecular chaperones and other molecules.
650		0	_aMedicine.
650		0	_aChemistry.
650		0	_aBiochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aBiochemistry, general.
650	2	4	_aChemistry/Food Science, general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400747159
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v985
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4716-6
912			_aZDB-2-SBL
999			_c99456 _d99456