000			03355nam a22004815i 4500
001			978-94-007-4590-2
003			DE-He213
005			20140220082933.0
007			cr nn 008mamaa
008			120726s2013 ne | s |||| 0|eng d
020			_a9789400745902 _9978-94-007-4590-2
024	7		_a10.1007/978-94-007-4590-2 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aMathews, Lesley A. _eeditor.
245	1	0	_aDNA Repair of Cancer Stem Cells _h[electronic resource] / _cedited by Lesley A Mathews, Stephanie M Cabarcas, Elaine M. Hurt.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aVI, 178 p. 10 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface. -1 Introduction to Cancer stem cells.-2 DNA Repair Pathways and Mechanisms.-3 Resistance and DNA repair mechanisms of cancer stem cells: Potential molecular targets for therapy.-4 DNA Repair in Normal Stem Cells.-5 DNA Repair Mechanisms in Glioblastoma Cancer Stem Cells.-6 DNA Repair Mechanisms in Breast Cancer Stem Cells.7 DNA Repair Mechanisms in other Cancer Stem Cell models -- 8 Pancreatic cancer stem cells in tumor progression, metastasis, epithelial-mesenchymal transition and DNA repair.-9 Targeting Cancer Stem Cell Efficient DNA Repair Pathways: Screening for new therapeutics -- 10 The Future of DNA Repair and Cancer Stem Cells. Index.
520			_aThe existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence.  CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aStem cells.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aMolecular Medicine.
650	2	4	_aCancer Research.
650	2	4	_aStem Cells.
700	1		_aCabarcas, Stephanie M. _eeditor.
700	1		_aHurt, Elaine M. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400745896
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4590-2
912			_aZDB-2-SBL
999			_c99434 _d99434