000 | 03505nam a22005295i 4500 | ||
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001 | 978-3-642-40232-6 | ||
003 | DE-He213 | ||
005 | 20140220082918.0 | ||
007 | cr nn 008mamaa | ||
008 | 131209s2013 gw | s |||| 0|eng d | ||
020 |
_a9783642402326 _9978-3-642-40232-6 |
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024 | 7 |
_a10.1007/978-3-642-40232-6 _2doi |
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050 | 4 | _aQR46 | |
072 | 7 |
_aMMFM _2bicssc |
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072 | 7 |
_aMED052000 _2bisacsh |
|
082 | 0 | 4 |
_a616.9041 _223 |
100 | 1 |
_aPieters, Jean. _eeditor. |
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245 | 1 | 0 |
_aPathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism _h[electronic resource] / _cedited by Jean Pieters, John D. McKinney. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2013. |
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300 |
_aVIII, 245 p. 22 illus., 11 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v374 |
|
505 | 0 | _aGenetic Diversity in Mycobacterium tuberculosis -- DNA Metabolism in Mycobacterial Pathogenesis -- Molecular Biology of Drug Resistance in Mycobacterium tuberculosis -- Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations -- Getting Across the Cell Envelope: Mycobacterial Protein Secretion -- A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria -- Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes -- Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis -- Host-Pathogen Interactions During Mycobacterium tuberculosis Infections. | |
520 | _aMycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aImmunology. | |
650 | 0 | _aMicrobiology. | |
650 | 0 | _aDrug interactions. | |
650 | 0 | _aMicrobial genetics. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aMedical Microbiology. |
650 | 2 | 4 | _aImmunology. |
650 | 2 | 4 | _aMolecular Medicine. |
650 | 2 | 4 | _aDrug Resistance. |
650 | 2 | 4 | _aMicrobial Genetics and Genomics. |
700 | 1 |
_aMcKinney, John D. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783642402319 |
830 | 0 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v374 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-40232-6 |
912 | _aZDB-2-SBL | ||
999 |
_c98574 _d98574 |