000 03505nam a22005295i 4500
001 978-3-642-40232-6
003 DE-He213
005 20140220082918.0
007 cr nn 008mamaa
008 131209s2013 gw | s |||| 0|eng d
020 _a9783642402326
_9978-3-642-40232-6
024 7 _a10.1007/978-3-642-40232-6
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aPieters, Jean.
_eeditor.
245 1 0 _aPathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism
_h[electronic resource] /
_cedited by Jean Pieters, John D. McKinney.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aVIII, 245 p. 22 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v374
505 0 _aGenetic Diversity in Mycobacterium tuberculosis -- DNA Metabolism in Mycobacterial Pathogenesis -- Molecular Biology of Drug Resistance in Mycobacterium tuberculosis -- Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations -- Getting Across the Cell Envelope: Mycobacterial Protein Secretion -- A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria -- Mycobacterium tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes -- Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis -- Host-Pathogen Interactions During Mycobacterium tuberculosis Infections.
520 _aMycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMicrobiology.
650 0 _aDrug interactions.
650 0 _aMicrobial genetics.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aImmunology.
650 2 4 _aMolecular Medicine.
650 2 4 _aDrug Resistance.
650 2 4 _aMicrobial Genetics and Genomics.
700 1 _aMcKinney, John D.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642402319
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v374
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-40232-6
912 _aZDB-2-SBL
999 _c98574
_d98574