000			04021nam a22005895i 4500
001			978-3-642-37555-2
003			DE-He213
005			20140220082909.0
007			cr nn 008mamaa
008			130625s2013 gw | s |||| 0|eng d
020			_a9783642375552 _9978-3-642-37555-2
024	7		_a10.1007/978-3-642-37555-2 _2doi
050		4	_aQH345
050		4	_aQD415-436
072		7	_aPSB _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572 _223
100	1		_aRahman, Masoud. _eauthor.
245	1	0	_aProtein-Nanoparticle Interactions _h[electronic resource] : _bThe Bio-Nano Interface / _cby Masoud Rahman, Sophie Laurent, Nancy Tawil, L'Hocine Yahia, Morteza Mahmoudi.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2013.
300			_aX, 84 p. 24 illus., 20 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Series in Biophysics, _x0932-2353 ; _v15
505	0		_aThe Biological Significance of ‘Nano’ interactions -- Nanoparticle and Protein Corona -- Protein Corona: Applications and Challenges -- Analytical Methods for Corona Evaluations.
520			_aIn recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
650		0	_aLife sciences.
650		0	_aToxicology.
650		0	_aBiochemistry.
650		0	_aRNA-ligand interactions.
650		0	_aNanotechnology.
650	1	4	_aLife Sciences.
650	2	4	_aBiochemistry, general.
650	2	4	_aProtein-Ligand Interactions.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aBiophysics and Biological Physics.
650	2	4	_aNanoscale Science and Technology.
650	2	4	_aNanotechnology.
700	1		_aLaurent, Sophie. _eauthor.
700	1		_aTawil, Nancy. _eauthor.
700	1		_aYahia, L'Hocine. _eauthor.
700	1		_aMahmoudi, Morteza. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642375545
830		0	_aSpringer Series in Biophysics, _x0932-2353 ; _v15
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-37555-2
912			_aZDB-2-PHA
999			_c98118 _d98118