000			02829nam a22004575i 4500
001			978-3-642-34657-6
003			DE-He213
005			20140220082858.0
007			cr nn 008mamaa
008			121213s2013 gw | s |||| 0|eng d
020			_a9783642346576 _9978-3-642-34657-6
024	7		_a10.1007/978-3-642-34657-6 _2doi
050		4	_aQR1-502
072		7	_aPSG _2bicssc
072		7	_aSCI045000 _2bisacsh
082	0	4	_a579 _223
100	1		_aBarrangou, Rodolphe. _eeditor.
245	1	0	_aCRISPR-Cas Systems _h[electronic resource] : _bRNA-mediated Adaptive Immunity in Bacteria and Archaea / _cedited by Rodolphe Barrangou, John van der Oost.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2013.
300			_aX, 299 p. 47 illus., 46 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aDiscovery and seminal developments in the CRISPR field -- Occurrence, diversity of CRISPR-Cas systems and genotyping implications --  Evolution and classification of CRISPR-Cas systems and Cas protein families -- Regulation of CRISPR-based immune responses -- crRNA Biogenesis -- Distribution and mechanism of the Type I CRISPR/Cas Systems -- Type II – Streptococcus thermophilus -- Type III CRISPR-Cas Systems and the Roles CRISPR-Cas in Bacterial Virulence -- CRISPR-Cas Systems to Probe Ecological Diversity and Host-Viral Interactions -- Roles of CRISPR in regulation of physiological processes -- Applications of the versatile CRISPR-Cas systems -- CRISPRs in microbial community context.
520			_aCRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered. In this book, experts summarize the state of the art of this exciting field.
650		0	_aLife sciences.
650		0	_aMicrobiology.
650		0	_aMicrobial genetics.
650	1	4	_aLife Sciences.
650	2	4	_aMicrobiology.
650	2	4	_aMicrobial Genetics and Genomics.
650	2	4	_aMedical Microbiology.
700	1		_avan der Oost, John. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642346569
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-34657-6
912			_aZDB-2-SBL
999			_c97548 _d97548