| 000 | 03175nam a22005055i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-32359-1 | ||
| 003 | DE-He213 | ||
| 005 | 20140220082852.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 121026s2013 gw | s |||| 0|eng d | ||
| 020 |
_a9783642323591 _9978-3-642-32359-1 |
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| 024 | 7 |
_a10.1007/978-3-642-32359-1 _2doi |
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| 050 | 4 | _aQD96.M3 | |
| 072 | 7 |
_aPNFS _2bicssc |
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| 072 | 7 |
_aSCI078000 _2bisacsh |
|
| 082 | 0 | 4 |
_a543.65 _223 |
| 100 | 1 |
_aWei, Huibin. _eauthor. |
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| 245 | 1 | 0 |
_aStudying Cell Metabolism and Cell Interactions Using Microfluidic Devices Coupled with Mass Spectrometry _h[electronic resource] / _cby Huibin Wei. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2013. |
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| 300 |
_aXVI, 102 p. 68 illus., 24 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
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| 505 | 0 | _aIntroduction -- Analysis of Herbicides on a Single C30 Bead via the Platform Combined Microfluidic Device with ESI-Q-TOF-MS -- Monitoring of Glutamate Release from Neuronal Cell Based on the Analysis Platform Combining the Microfluidic Devices with ESI-Q-TOF-MS -- Microfluidic Device with Integrated Porous Membrane for Cell Sorting and Separation -- Cell Co-culture and Signaling Analysis Based on Microfluidic Devices Coupling with ESI-Q-TOF-MS. | |
| 520 | _aThis thesis describes a new approach for cell analysis by the rapid developing microfluidic technology. The nominee has made great contributions to develop a new analysis platform which combined microfluidic devices with mass spectrometry to determine the trace compounds secreted by cells. Based on this analysis platform, she studied the specific cell secreting behaviors under controlled microenvironment, of which the secretion compounds were qualified and semi-quantified by mass spectrometry. A novel cell sorting device integrated homogenous porous PDMS membrane was invented to classify cells from real samples based on the size difference. The nominee further studied the signal transmission between different cells, and the signal chemicals were qualitative and quantitative monitored by the analysis platform. This indicates the potential significant application of the new cell analysis platform in medicine screening and early diagnosis. | ||
| 650 | 0 | _aChemistry. | |
| 650 | 0 | _aAnalytical biochemistry. | |
| 650 | 0 | _aMass spectrometry. | |
| 650 | 0 | _aCytology. | |
| 650 | 0 | _aEngineering. | |
| 650 | 1 | 4 | _aChemistry. |
| 650 | 2 | 4 | _aMass Spectrometry. |
| 650 | 2 | 4 | _aNanotechnology and Microengineering. |
| 650 | 2 | 4 | _aCell Biology. |
| 650 | 2 | 4 | _aAnalytical Chemistry. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783642323584 |
| 830 | 0 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-32359-1 |
| 912 | _aZDB-2-CMS | ||
| 999 |
_c97229 _d97229 |
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