000			02959nam a22005415i 4500
001			978-3-0348-0688-6
003			DE-He213
005			20140220082836.0
007			cr nn 008mamaa
008			130828s2013 sz | s |||| 0|eng d
020			_a9783034806886 _9978-3-0348-0688-6
024	7		_a10.1007/978-3-0348-0688-6 _2doi
050		4	_aQH345
050		4	_aQD415-436
072		7	_aPSBC _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572.696 _223
100	1		_aKutikhin, Anton G. _eauthor.
245	1	0	_aGenomics of Pattern Recognition Receptors _h[electronic resource] : _bApplications in Oncology and Cardiovascular Diseases / _cby Anton G. Kutikhin, Arseniy E. Yuzhalin.
264		1	_aBasel : _bSpringer Basel : _bImprint: Springer, _c2013.
300			_aXI, 185 p. 2 illus., 1 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation -- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword -- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer -- Structural Genomic Variation in Other Toll-like Receptors and Cancer -- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer -- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer -- Structural Genomic Variation in NOD-Like Receptors and Cancer -- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases -- Hot Spots In the Field: Where Should We Go.
520			_aThis book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
650		0	_aLife sciences.
650		0	_aOncology.
650		0	_aHuman genetics.
650		0	_aImmunology.
650		0	_aCardiology.
650		0	_aCell receptors.
650	1	4	_aLife Sciences.
650	2	4	_aReceptors.
650	2	4	_aImmunology.
650	2	4	_aCancer Research.
650	2	4	_aHuman Genetics.
650	2	4	_aOncology.
650	2	4	_aCardiology.
700	1		_aYuzhalin, Arseniy E. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034806879
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0348-0688-6
912			_aZDB-2-SBL
999			_c96329 _d96329