000			03478nam a22004575i 4500
001			978-1-62703-420-3
003			DE-He213
005			20140220082834.0
007			cr nn 008mamaa
008			130419s2013 xxu| s |||| 0|eng d
020			_a9781627034203 _9978-1-62703-420-3
024	7		_a10.1007/978-1-62703-420-3 _2doi
050		4	_aQH345
050		4	_aQD415-436
072		7	_aPSB _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572 _223
100	1		_aYoussef, Jihan A. _eauthor.
245	1	0	_aPeroxisome Proliferator-Activated Receptors _h[electronic resource] : _bDiscovery and Recent Advances / _cby Jihan A. Youssef, Mostafa Z. Badr.
264		1	_aTotowa, NJ : _bHumana Press : _bImprint: Humana Press, _c2013.
300			_aIX, 137 p. 14 illus., 5 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction.- History of PPAR Discovery: Peroxisomes -- Peroxisomal biogenesis and diseases -- Peroxisome proliferation.- Peroxisome Proliferator-Activated Receptors: Chromosomal location and gene polymorphism -- Protein structure -- PPAR Ligands: Endogenous ligands -- Exogenous PPAR modulators -- Tissue Distribution and Versatile Functions of PPARs: Neurological functions of PPARs.- PPARs and the cardiovascular system.- PPARs in pulmonary physiology and disease.- Gastrointestinal roles of PPARs.- PPAR functions in the liver.- Roles of PPARs in the pancreas.- PPARs in the urinary tract physiology and pathophysiology.- PPARs in the reproductive system -- Bone metabolism and PPARs.- Roles of PPARs in skeletal muscle biology.- Skin PPARs.- PPARs and Drug Metabolism -- Molecular Aspects of PPAR Actions: Posttranslational control of PPARs.- Mechanism of action.- Animal Models in PPAR Research.- Safety of PPAR Agonists.- The Future of PPAR Research.
520			_aAll three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described.   As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.
650		0	_aLife sciences.
650		0	_aBiochemistry.
650		0	_aCell receptors.
650	1	4	_aLife Sciences.
650	2	4	_aBiochemistry, general.
650	2	4	_aReceptors.
700	1		_aBadr, Mostafa Z. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781627034197
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-62703-420-3
912			_aZDB-2-SBL
999			_c96199 _d96199