000 04456nam a22004815i 4500
001 978-1-62703-200-1
003 DE-He213
005 20140220082834.0
007 cr nn 008mamaa
008 121211s2013 xxu| s |||| 0|eng d
020 _a9781627032001
_9978-1-62703-200-1
024 7 _a10.1007/978-1-62703-200-1
_2doi
050 4 _aQH588.S83
072 7 _aPSAK
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aChase, Lucas G.
_eeditor.
245 1 0 _aMesenchymal Stem Cell Therapy
_h[electronic resource] /
_cedited by Lucas G. Chase, Mohan C. Vemuri.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana Press,
_c2013.
300 _aXII, 453 p. 32 illus., 20 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aStem Cell Biology and Regenerative Medicine
505 0 _aScaling-up Ex-vivo Expansion of Mesenchymal Stem/Stromal Cells for Cellular Therapies -- Mesenchymal Stromal Cell Mechanisms of Immunomodulation and Homing -- Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy? -- The Biology of Mesenchymal Stem Cells in Health and Disease and its Relevance to MSC-based Cell Delivery Therapies -- Pulmonary Clinical Applications for Mesenchymal Stem Cells -- Stem Cell Therapy for Bone Disorders -- Mesenchymal Stem Cell Therapies for Bone and Tendon Conditions -- Mesenchymal Stromal Cells (MSC) and the Repair of Cartilage Tissue -- Mesenchymal Stem Cells and Haematopoietic Stem Cell Culture -- Mesenchymal Stem Cells for Treatment and Prevention of Graft-Versus-Host Disease and Graft Failure after Hematopoietic Stem Cell Transplantation and Future Challenges -- Mesenchymal Stromal Cell Therapy in Crohn’s Disease -- Application of Mesenychymal Stem Cells in Amyotrophic Lateral Sclerosis -- Mesenchymal Stem Cell Therapy for Heart Disease -- Advances in Lentivector-based Cell Therapy with Mesenchymal Stem Cells -- Genetically Engineered Mesenchymal Stem Cells for Cell and Gene Therapy -- Optimal Tissue Sources of Mesenchymal Stromal Cells for Clinical Trials -- Regulatory Considerations Applicable to Manufacturing of Human Placenta-derived Mesenchymal Stromal Cells (MSC) Used in Clinical Trials in Australia and Comparison to USA and European Regulatory Frameworks -- Mesenchymal Stem Cell Therapy for Peripheral Vascular Diseases -- Mesenchymal Stromal Cells in the Clinic: What do the clinical trials say?.
520 _aMesenchymal Stem Cells or Multipotent Mesenchymal Stromal Cells (collectively referred to as MSCs) are currently being tested in a number of clinical trials for various diseases including graft-versus-host disease, Crohn’s disease, myocardial infarction, stroke, diabetes, cartilage defects, and many others. The increasing number of clinical trials globally indicates the likely therapeutic potential of this specialized adult stem cell.  Over the last decade, there has been tremendous progress towards understanding an MSC’s phenotype, expansion features in culture, differentiation ability and global gene and protein expression profiles.  Despite the enormous progress and data accrual at the molecular and cellular levels, several questions remain as to the utility of MSCs for clinical applications.    Mesenchymal Stem Cell Therapy is a comprehensive collection of information comprised of both basic and pre-clinical biological studies as well as current advances in clinical applications within the MSC therapy field.  This text is a resource for both the basic life science and cell therapy researchers and includes a spectrum of review chapters from top experts in the field discussing clinical scale culture, regulatory issues, genetic engineering, disease specific applications and others.
650 0 _aLife sciences.
650 0 _aCytology.
650 0 _aStem cells.
650 1 4 _aLife Sciences.
650 2 4 _aStem Cells.
650 2 4 _aCell Biology.
700 1 _aVemuri, Mohan C.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781627031998
830 0 _aStem Cell Biology and Regenerative Medicine
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-62703-200-1
912 _aZDB-2-SBL
999 _c96183
_d96183