000			03761nam a22005175i 4500
001			978-1-62703-164-6
003			DE-He213
005			20140220082834.0
007			cr nn 008mamaa
008			121205s2013 xxu| s |||| 0|eng d
020			_a9781627031646 _9978-1-62703-164-6
024	7		_a10.1007/978-1-62703-164-6 _2doi
050		4	_aRM1-950
072		7	_aMMG _2bicssc
072		7	_aMED071000 _2bisacsh
082	0	4	_a615 _223
100	1		_aWeir, Andrea B. _eeditor.
245	1	0	_aAssessing Ocular Toxicology in Laboratory Animals _h[electronic resource] / _cedited by Andrea B Weir, Margaret Collins.
264		1	_aTotowa, NJ : _bHumana Press : _bImprint: Humana Press, _c2013.
300			_aXIV, 319 p. 120 illus., 75 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMolecular and Integrative Toxicology, _x2168-4219
505	0		_aComparative Ocular Anatomy in Commonly Used Laboratory Animals -- Assessment of Ocular Toxicity Potential: Basic Theory and Techniques -- Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals -- Toxicologic Pathology of the Eye:  Histologic Preparation and Alterations of the Anterior Segment -- Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment -- Nonclinical Regulatory Aspects for Ophthalmic Drugs -- Ocular Toxicity Regulatory Considerations for Non-Drug Food and Drug.
520			_aOcular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes.  Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes.  The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
650		0	_aMedicine.
650		0	_aToxicology.
650		0	_aOphthalmology.
650		0	_aMorphology (Animals).
650		0	_aLaboratory animals.
650	1	4	_aBiomedicine.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aOphthalmology.
650	2	4	_aAnimal Models.
650	2	4	_aAnimal Anatomy / Morphology / Histology.
700	1		_aCollins, Margaret. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781627031639
830		0	_aMolecular and Integrative Toxicology, _x2168-4219
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-62703-164-6
912			_aZDB-2-SBL
999			_c96176 _d96176