000			02872nam a22005055i 4500
001			978-1-4614-8357-1
003			DE-He213
005			20140220082831.0
007			cr nn 008mamaa
008			131010s2013 xxu| s |||| 0|eng d
020			_a9781461483571 _9978-1-4614-8357-1
024	7		_a10.1007/978-1-4614-8357-1 _2doi
050		4	_aQH588.S83
072		7	_aPSAK _2bicssc
072		7	_aSCI017000 _2bisacsh
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aBoelens, Jaap Jan. _eeditor.
245	1	0	_aStem Cell Therapy in Lysosomal Storage Diseases _h[electronic resource] / _cedited by Jaap Jan Boelens, Robert Wynn.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Humana Press, _c2013.
300			_aIX, 171 p. 6 illus., 3 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aStem Cell Biology and Regenerative Medicine, _x2196-8985
505	0		_a1. Lysosomal Diseases and Therapeutic Options: An Overview -- 2. Alternative Treatment Options: Enzyme Replacement and Small Molecule Therapies -- 3. Hematopoietic Cell Transplantation in Inborn Errors of Metabolism -- 4. Allogeneic Hematopoietic Stem Cell Transplantation in Lysosomal Storage Disorders: Long Term Neurodevelopmental and Somatic Outcome -- 5. Hematopoietic Stem Cell Gene Therapy for Lysosomal Storage Disorders: Expected Benefits and Limitations -- 6. Alternative Future Therapies for Lysosomal Storage Diseases: Embryonic Stem Cell- and Induced Pluripotent Stem Cell Therapy -- 7. New Directions and Conclusions.
520			_aStem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e.g. gene therapy, iPS, ES) in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.
650		0	_aLife sciences.
650		0	_aHuman genetics.
650		0	_aCytology.
650		0	_aStem cells.
650	1	4	_aLife Sciences.
650	2	4	_aStem Cells.
650	2	4	_aCell Biology.
650	2	4	_aHuman Genetics.
700	1		_aWynn, Robert. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461483564
830		0	_aStem Cell Biology and Regenerative Medicine, _x2196-8985
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-8357-1
912			_aZDB-2-SBL
999			_c96048 _d96048