000 | 03601nam a22004575i 4500 | ||
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001 | 978-1-4614-7660-3 | ||
003 | DE-He213 | ||
005 | 20140220082830.0 | ||
007 | cr nn 008mamaa | ||
008 | 130716s2013 xxu| s |||| 0|eng d | ||
020 |
_a9781461476603 _9978-1-4614-7660-3 |
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024 | 7 |
_a10.1007/978-1-4614-7660-3 _2doi |
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050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
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072 | 7 |
_aMED062000 _2bisacsh |
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082 | 0 | 4 |
_a614.5999 _223 |
100 | 1 |
_aKolonin, Mikhail G. _eeditor. |
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245 | 1 | 0 |
_aAdipose Tissue and Cancer _h[electronic resource] / _cedited by Mikhail G. Kolonin. |
264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013. |
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300 |
_aVIII, 190 p. 15 illus., 11 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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505 | 0 | _aPreface: Obesity, Adipose Tissue and Cancer Progression -- Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link -- Increased Adiposity and Colorectal Cancer -- Adiposity and Diabetes in Breast and Prostate Cancer -- Increased Adipocity and Endometrial Cancer Risk -- Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer -- Animal Models to Study the Interplay between Cancer and Obesity -- Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved -- Trafficking of Cells from Adipose Tissue to Tumor Microenvironment -- The Impact of Obesity Intervention on Cancer: Clinical Perspectives -- Index. | |
520 | _aThe pathophysiology underlying the relationship between obesity and cancer is complex and incompletely understood. Progression of certain cancers has been shown to accelerate in obese patients irrespective of their lifestyle and diet. Because obesity is manifested by overgrowth of white adipose tissue, it has been proposed that adipose tissue has a direct effect on cancer progression. Adipose tissue is composed of several types of cells secreting numerous soluble factors collectively termed adipokines. In addition, infiltration of the immune system cells in obesity leads to increased production of a number of inflammatory factors by adipose tissue, thus contributing to the establishment of the metabolic syndrome. Endocrine signaling by adipose tissue-derived molecules has been shown to promote cancer in animal models, matching clinical associations. Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. This volume will discuss clinical and experimental data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aOncology. | |
650 | 0 | _aLipids. | |
650 | 0 | _aCytology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aLipidology. |
650 | 2 | 4 | _aCell Biology. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781461476597 |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-7660-3 |
912 | _aZDB-2-SBL | ||
999 |
_c95958 _d95958 |