000			03577nam a22004695i 4500
001			978-1-4614-7294-0
003			DE-He213
005			20140220082828.0
007			cr nn 008mamaa
008			130709s2013 xxu| s |||| 0|eng d
020			_a9781461472940 _9978-1-4614-7294-0
024	7		_a10.1007/978-1-4614-7294-0 _2doi
050		4	_aQR355-502
072		7	_aMMFM _2bicssc
072		7	_aMED052000 _2bisacsh
082	0	4	_a616.9101 _223
100	1		_aWick, W David. _eauthor.
245	1	0	_aWar in the Body _h[electronic resource] : _bThe Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines / _cby W David Wick, Otto O Yang.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXIX, 298 p. 51 illus., 4 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThe HIV Infection model -- The CTL Model -- Simulating an HIV Infection In Vivo -- The Escape Formula -- Early and Late Escapes -- Understanding Escape -- More Topics about Escape from Immune Control -- HIV's Cloaking Device: The Fascinating Story of Nef -- Retroviral Sex and Escape -- The Ne Business Again and a Proposed Experiment -- Can a T-cell Vaccine Block Escape? -- The STEP Trial and the Future of T-cell Vaccines -- Short Tutorial on Dynamical Models -- Deterministic Modeling: A Cautionary Example -- The Infection Model Defined -- The CTL Model Defined -- On Simulation Techniques -- Derivation of the Escape Formula -- Statistics of the Mutant Lineage in Classical Genetics -- Extinction Probabilities with Extra Poisson Variation -- Computing the Boundaries -- Co-existence or Replacement? -- The Nef-Deletion Threshold Formulas -- Modeling Retroviral Sex.
520			_aIn the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.
650		0	_aMedicine.
650		0	_aImmunology.
650		0	_aVaccines.
650		0	_aMedical virology.
650	1	4	_aBiomedicine.
650	2	4	_aVirology.
650	2	4	_aImmunology.
650	2	4	_aVaccine.
700	1		_aYang, Otto O. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461472933
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-7294-0
912			_aZDB-2-SBL
999			_c95892 _d95892