000			05024nam a22005415i 4500
001			978-1-4614-5203-4
003			DE-He213
005			20140220082819.0
007			cr nn 008mamaa
008			121026s2013 xxu| s |||| 0|eng d
020			_a9781461452034 _9978-1-4614-5203-4
024	7		_a10.1007/978-1-4614-5203-4 _2doi
050		4	_aRB112.5
072		7	_aPSB _2bicssc
072		7	_aMED008000 _2bisacsh
082	0	4	_a612.015 _223
100	1		_aOstadal, Bohuslav. _eeditor.
245	1	0	_aCardiac Adaptations _h[electronic resource] : _bMolecular Mechanisms / _cedited by Bohuslav Ostadal, Naranjan S. Dhalla.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXVII, 465 p. 74 illus., 38 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Biochemistry in Health and Disease ; _v4
505	0		_aComparative Aspects of Cardiac Adaptation -- Molecular Mechanisms in Cardiac Development -- Prenatal Adaptation to Overload -- Hypoxia and Mechanical Factors Drive Coronary Vascular Development -- Cardiac Metabolic Adaptation During Postnatal Development -- Ontogenetic Adaptation to Chronic Hypoxia -- Heart and Arterial Aging -- Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy -- Cardiac Adaptation to Volume Overload -- Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females -- Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations -- Cardiopulmonary Adaptation to High Altitude -- Cardiac Hypertrophy in Hypertension -- Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice -- The Athlete’s Heart -- Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy -- Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy -- Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart -- Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy -- Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection -- Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor -- Myocardial Adaptation and Autophagy -- Modulatory Role of VEGF in Angiogenesis for Cell Survival -- The Role of CaM Kinase II in Cardiac Function in Health and Disease.
520			_aThe processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases.  The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging.  The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations.  The third section of this volume highlights the roles of sympathetic nervous system with respect to α-adrenoceptor and β-adrenoceptor mechanisms in the development of cardiac hypertrophy.  Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
650		0	_aMedicine.
650		0	_aHuman physiology.
650		0	_aCardiology.
650		0	_aBiochemistry.
650		0	_aCell receptors.
650	1	4	_aMedicine & Public Health.
650	2	4	_aMedical Biochemistry.
650	2	4	_aMolecular Medicine.
650	2	4	_aCardiology.
650	2	4	_aBiochemistry, general.
650	2	4	_aReceptors.
650	2	4	_aHuman Physiology.
700	1		_aDhalla, Naranjan S. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461452027
830		0	_aAdvances in Biochemistry in Health and Disease ; _v4
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-5203-4
912			_aZDB-2-SBL
999			_c95344 _d95344