000 | 03654nam a22005175i 4500 | ||
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001 | 978-1-4614-4954-6 | ||
003 | DE-He213 | ||
005 | 20140220082817.0 | ||
007 | cr nn 008mamaa | ||
008 | 121206s2013 xxu| s |||| 0|eng d | ||
020 |
_a9781461449546 _9978-1-4614-4954-6 |
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024 | 7 |
_a10.1007/978-1-4614-4954-6 _2doi |
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_aMBGR _2bicssc |
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_aMED067000 _2bisacsh |
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_a611.01816 _223 |
100 | 1 |
_aRussell, Rick. _eeditor. |
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245 | 1 | 0 |
_aBiophysics of RNA Folding _h[electronic resource] / _cedited by Rick Russell. |
264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013. |
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300 |
_aVI, 236 p. 71 illus., 55 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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_atext file _bPDF _2rda |
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490 | 1 |
_aBiophysics for the Life Sciences ; _v3 |
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505 | 0 | _aIntroduction -- Comparative Analysis of the Higher-order Structure of RNA -- Graph Applications to RNA Structure and Function -- Prediction and Coarse-Grained Modeling of RNA Structures -- RNA Folding Using Site-Directed Spin Labeling -- The RNA Recognition Motif and Messenger RNA -- Memory Effects in RNA folding dynamics revealed by single molecule fluorescence -- An integrated picture of HDV ribozyme catalysis -- Combining biochemical and structural information to model RNA-protein complex assembly -- Following RNA Folding From Local and Global Perspectives -- The Roles of Chaperones in RNA Folding. | |
520 | _aStructured RNAs are everywhere, functioning throughout gene expression with key roles ranging from catalysis to regulation. New functional RNAs are being discovered all the time; in fact, it is now clear that a much greater fraction of eukaryotic genomes is devoted to coding for RNA than protein. Many of these RNAs must traverse complex energy landscapes to find their functional three-dimensional structures. Along the way, they may encounter native and non-native folding intermediates, chaperone proteins, and assemble with partner proteins. This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aBiochemistry. | |
650 | 0 | _aNucleic acids. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aMolecular Medicine. |
650 | 2 | 4 | _aBiophysics and Biological Physics. |
650 | 2 | 4 | _aBiochemistry, general. |
650 | 2 | 4 | _aNucleic Acid Chemistry. |
650 | 2 | 4 | _aSingle Molecule Studies, Molecular Motors. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781461449539 |
830 | 0 |
_aBiophysics for the Life Sciences ; _v3 |
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856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-4954-6 |
912 | _aZDB-2-SBL | ||
999 |
_c95269 _d95269 |