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001 978-1-4614-4954-6
003 DE-He213
005 20140220082817.0
007 cr nn 008mamaa
008 121206s2013 xxu| s |||| 0|eng d
020 _a9781461449546
_9978-1-4614-4954-6
024 7 _a10.1007/978-1-4614-4954-6
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aRussell, Rick.
_eeditor.
245 1 0 _aBiophysics of RNA Folding
_h[electronic resource] /
_cedited by Rick Russell.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aVI, 236 p. 71 illus., 55 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aBiophysics for the Life Sciences ;
_v3
505 0 _aIntroduction -- Comparative Analysis of the Higher-order Structure of RNA -- Graph Applications to RNA Structure and Function -- Prediction and Coarse-Grained Modeling of RNA Structures -- RNA Folding Using Site-Directed Spin Labeling -- The RNA Recognition Motif and Messenger RNA -- Memory Effects in RNA folding dynamics revealed by single molecule fluorescence -- An integrated picture of HDV ribozyme catalysis -- Combining biochemical and structural information to model RNA-protein complex assembly -- Following RNA Folding From Local and Global Perspectives -- The Roles of Chaperones in RNA Folding.
520 _aStructured RNAs are everywhere, functioning throughout gene expression with key roles ranging from catalysis to regulation. New functional RNAs are being discovered all the time; in fact, it is now clear that a much greater fraction of eukaryotic genomes is devoted to coding for RNA than protein. Many of these RNAs must traverse complex energy landscapes to find their functional three-dimensional structures. Along the way, they may encounter native and non-native folding intermediates, chaperone proteins, and assemble with partner proteins. This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aNucleic acids.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aBiophysics and Biological Physics.
650 2 4 _aBiochemistry, general.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aSingle Molecule Studies, Molecular Motors.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461449539
830 0 _aBiophysics for the Life Sciences ;
_v3
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4954-6
912 _aZDB-2-SBL
999 _c95269
_d95269