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001 978-1-4614-4409-1
003 DE-He213
005 20140220082815.0
007 cr nn 008mamaa
008 120830s2013 xxu| s |||| 0|eng d
020 _a9781461444091
_9978-1-4614-4409-1
024 7 _a10.1007/978-1-4614-4409-1
_2doi
050 4 _aQH359-425
072 7 _aPSAJ
_2bicssc
072 7 _aSCI027000
_2bisacsh
082 0 4 _a576.8
_223
100 1 _aWatve, Milind.
_eauthor.
245 1 0 _aDoves, Diplomats, and Diabetes
_h[electronic resource] :
_bA Darwinian Interpretation of Type 2 Diabetes and Related Disorders /
_cby Milind Watve.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXII, 380 p. 60 illus., 35 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _a1. A Darwinian Way of Thinking -- 2. Diabetes in a Textbook -- 3. Diabetes in an Undergraduate Class -- 4. The Rise and Fall of Thrift -- 5. Of Hawks and Doves -- 6. Of Soldiers and Diplomats -- 7. The Physiology of Aggression -- 8. Deploying the Immunological Garrison -- 9. Why Population Density Matters -- 10. Time to Give up Stress -- 11. Fat: Beyond Energy Storage -- 12. Why Blood Sugar Goes up -- 13. Beating Around the ‘Wrong’ Bush? -- 14. Behavioral Deficiencies and Behavioral Supplementation: -- 15. Where do we Go From Here? -- Appendix I. Genes/molecules that are associated with aggression and also associated with some component of metabolic syndrome -- Appendix II. Network model of type 2 diabetes -- Appendix III. Model for the Effect of population density on aggression -- Appendix IV. Glucose homeostasis model.
520 _aType 2 diabetes, obesity and other lifestyle disorders are a growing health concern in the modern world. Despite decades of research and worldwide efforts, there are no signs of curbing the growing epidemic. It is time to rethink whether there is something fundamentally wrong in our understanding of the origins and the etiology of these disorders. A probe into evolutionary origins of the disorders is likely to give us new insights into the basic biology behind them. Reviewing prior hypotheses of the evolutionary origins of type 2 diabetes, Dr. Milind Watve takes several important steps toward a radically different perspective. Based on an extensive compilation and reinterpretation of research over the last two decades, Doves, Diplomats, and Diabetes challenges some of the prevalent theories, including whether obesity is central to insulin resistance, whether insulin resistance is central to type 2 diabetes and whether raised blood sugar is the real cause of the diabetic complications. What emerges is an alternative interpretation of type 2 diabetes and related disorders. Behavior is proposed to be an important driver of endocrine and metabolic state. This book illustrates specific links between behavior and metabolism and demonstrates how the deficiency of certain stone-age behaviors is leading to modern health problems. It demonstrates how brain and behavior regulate glucose dynamics in the body. The concept of behavioral deficiency disorders is a potential paradigm shift that would stimulate research is a new direction. The central arguments in the book are based on substantial backing from epidemiological and experimental evidence, systems-level analysis and mathematical models. In spite of the inherent complexity of the subject the book is written with a style that makes it readable to any reader interested in basic biology, evolution, medicine or health.
650 0 _aLife sciences.
650 0 _aHuman physiology.
650 0 _aDiabetes.
650 0 _aEvolution (Biology).
650 0 _aAnimal Physiology.
650 1 4 _aLife Sciences.
650 2 4 _aEvolutionary Biology.
650 2 4 _aDiabetes.
650 2 4 _aHuman Physiology.
650 2 4 _aAnimal Physiology.
650 2 4 _aHuman Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461444084
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-4409-1
912 _aZDB-2-SBL
999 _c95132
_d95132