000 03414nam a22005055i 4500
001 978-1-4614-3697-3
003 DE-He213
005 20140220082812.0
007 cr nn 008mamaa
008 120905s2013 xxu| s |||| 0|eng d
020 _a9781461436973
_9978-1-4614-3697-3
024 7 _a10.1007/978-1-4614-3697-3
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aZhang, Huang-Ge.
_eeditor.
245 1 0 _aEmerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication
_h[electronic resource] /
_cedited by Huang-Ge Zhang.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aVII, 220 p. 34 illus., 20 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- The Cell Biology of Exosomes : Historical and Perspectives -- The role of exosomal shuttle RNA (esRNA) in cell-to-cell -- Exosomal lipids in cell-cell communication -- The Functional Importance Of Tetraspanins In Exosomes -- The effects of exosomes and related vesicles on cancer development, progression, and dissemination -- Circulating Cell-derived Vesicles Mediate Tumor Progression -- Immune modulation of T cells and natural killer cells by tumor-derived exosomes -- The Role Of Tumor Exosomes In Tumorigenicity -- Microenvironmental regulation of metastasis by exosomes -- Microvesicles and their Emerging Role in Cellular Therapies for Organ and Tissue Regeneration -- Index.
520 _aTumor exsome-mediated cell-cell communication has grown increasingly important in cancer research. Recent findings on vesicle-based information transfer by exosomes have changed our view of the tumor microenvironment.  Currently, exosomes represent the main extracellular processes implicated in the regulation of multiple physiological processes. Importantly, in cancer, exosomes contribute to the formation of the tumor microenvironment, promoting invasion, angiogenesis, immune regulation and metastasis. Therefore, exosomes could be considered one of the major forces acting locally or systemically to promote the continuous crosstalk between the tumor and its microenvironment, influencing the behavior of different cell types such as stromal, endothelial and bone marrow-derived cells. Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. This volume gives a comprehensive review on current research in this area and also discuss future prospects as prognostic markers for cancer.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 0 _aBiochemistry.
650 0 _aPost-translational modification of proteins.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aCell Biology.
650 2 4 _aPosttranslational Modification.
650 2 4 _aProtein Science.
650 2 4 _aImmunology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461436966
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-3697-3
912 _aZDB-2-SBL
999 _c95003
_d95003