000			03741nam a22004455i 4500
001			978-1-4614-3685-0
003			DE-He213
005			20140220082812.0
007			cr nn 008mamaa
008			130107s2013 xxu| s |||| 0|eng d
020			_a9781461436850 _9978-1-4614-3685-0
024	7		_a10.1007/978-1-4614-3685-0 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aBurnier, Julia V. _eeditor.
245	1	0	_aExperimental and Clinical Metastasis _h[electronic resource] : _bA Comprehensive Review / _cedited by Julia V. Burnier, Miguel N. Burnier, Jr.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXVI, 472 p. 65 illus., 51 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- Interactions of Normal Tissues and Systems with Metastatic Cells: Impact on Location, Survival and Growth -- Introduction to Metastasis Suppressor Genes -- Metastasis suppressor genes -- Metastatic Dormancy & Metastatic Suppressor Genes -- Clinical Implications -- Growth Factor Systems and Cell Cycle Regulation -- Angiogenesis -- Inflammatory mediators in Tumorigenesis and Metastasis -- Role of stroma in disease progression -- Local spread -- Lymphatic – GI tract and Breast Cancer -- Hematogenous – Uveal Melanoma -- Other methods -- Haematogenous Models of Metastases -- Spontaneous, Induced, and Transgenic Models of Metastasis -- Orthotopic and Ectopic Models of Metastasis -- Animal Model Imaging Techniques -- Diagnosis of Metastasis -- Cancer Staging -- Diagnostic Immunohistochemistry in Tumor metastasis -- Genomics and Proteomics -- The role of chemotherapy for metastatic disease -- Integrating chemotherapy to surgery: Novel approaches in regionally aggressive cancer metastasis -- Palliative radiation therapy -- Role of Surgery in the Diagnosis and Management of Metastatic Cancer -- Prerequisite genetic traits for metastasis -- Metastasis Initiation -- Index.
520			_aThe primary cause of death related to cancers can be traced back to metastases, originated from cancer cells. The presence of metastatic disease, the spread of cancer cells, is the most important prognostic and survival factor in patients with cancer. Although treatment of the primary tumor is well established and usually results in local control, treating metastatic disease is a much more daunting task. At diagnosis, few patients present with clinically detectable metastatic lesions regardless of the clinical prognostic factor. Clinical trials assessing potential therapeutic agents are important in order to define the best specific treatment for a particular patient, which are the basis for patient-oriented research that eventually lead to personalized medicine. This volume aims to comprehensively present the latest research and information about metastasis. Understanding the mechanisms underlying the metastatic phenomenon could have vast implications for the large number of patients who are at a high risk for the development of metastasis.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aPharmacology/Toxicology.
700	1		_aBurnier, Jr., Miguel N. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461436843
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-3685-0
912			_aZDB-2-SBL
999			_c95002 _d95002