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001 978-1-4471-4881-4
003 DE-He213
005 20140220082807.0
007 cr nn 008mamaa
008 130423s2013 xxk| s |||| 0|eng d
020 _a9781447148814
_9978-1-4471-4881-4
024 7 _a10.1007/978-1-4471-4881-4
_2doi
050 4 _aRC681-688.2
072 7 _aMJD
_2bicssc
072 7 _aMED010000
_2bisacsh
082 0 4 _a616.12
_223
100 1 _aGussak, Ihor.
_eeditor.
245 1 0 _aElectrical Diseases of the Heart
_h[electronic resource] :
_bVolume 1: Basic Foundations and Primary Electrical Diseases /
_cedited by Ihor Gussak, Charles Antzelevitch.
250 _a2nd ed. 2013.
264 1 _aLondon :
_bSpringer London :
_bImprint: Springer,
_c2013.
300 _aXXI, 659 p. 201 illus., 98 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aBasic Cardiac Electrophysiology- Promises Kept and Promises to Keep -- Basic Physiology of Ion Channel Function -- Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form -- Anatomic and Histopathologic Characteristics of the Conductive Tissues of the Heart -- Neural Regulation of the Heart in Health and Disease -- Mechanisms of Cardiac Arrhythmia -- Mechanisms of Action of Antiarrhythmic Drugs in Ventricular Arrhythmias -- Mechanisms of Action of Antiarrhythmic Drugs in Atrial Fibrillation -- Mechano-Electrical Interactions and their Role in Electrical Function of the Heart -- Pathological Roles of the Cardiac Sodium Channel Late Current (late INa) -- Sodium Ion Channelopathies -- L-Type Calcium Channel Disease -- Nerve Sprouting, Defibrillation and Calcium Waves -- K+ Channelopathies (IKs, IKr, and Ito) -- Cardiac ATP-Sensitive Potassium Channels and Associated Channelopathies -- Cardiac KATP Channels in Health and Diseases -- Ca2+ Release Channels (Ryanodine Receptors) and Arrhythmogenesis -- Caveolae and Arrhythmogenesis -- Senescence and Arrhythmogenesis -- Comparisons of Substrates Responsible for Atrial versus Ventricular Fibrillation -- Single Nucleotide Polymorphisms in Health and Cardiac Disease -- Electrophysiological Remodeling in Heart Failure -- Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy -- Physiological and Other Biological Pacemakers -- Cardiac Memory: From Electrical Curiosity to Clinical Diagnostic and Research Tool -- Heritable Arrhythmogenic Channelopathies, Primary Electrical Diseases, and Sudden Cardiac Death -- Celebrating the Challenge of Cardiac Arrhythmias -- Congenital Long QT Syndrome -- Brugada Syndrome – Clinical and Genetic Aspects -- Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy -- Early Repolarization Syndrome: Epidemiology, Genetics, and Risk Stratification -- Catecholaminergic Polymorphic Ventricular Tachycardia -- Andersen-Tawil and Timothy Syndromes -- Short QT Syndrome -- Progressive Cardiac Conduction Disease -- Genetics of Atrial Fibrillation -- Idiopathic Ventricular Fibrillation.              .
520 _aThe past two decades have witnessed an explosion of knowledge and radical changes in our understanding of the molecular, ionic, genetic, and pharmacologic basis of electrical diseases of the heart. Electrical diseases of the heart are heritable arrhythmogenic clinical entities that may share common clinical and genetic features, yet may be distinctly different in their genesis, prognosis, and management. Notably, both congenital and acquired electrical diseases of the heart are receiving increased recognition as a result of important advances in genetic analysis.   In this second edition of Electrical Diseases of the Heart, the Editors’ goal has been to embrace and highlight the explosion of knowledge that our field has witnessed since the publication of the first edition.  The approach continues to be one of bridging basic and clinical science in an attempt to advance meaningfully our understanding of heart disease and identify the knowledge gaps that exist. This volume covers the basic foundations and primary electrical diseases and with the companion volume provides the latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities.   Residents, fellows and physicians in cardiology and electrophysiology will gain valuable insight into the latest developments in the field of cardiac electrophysiology and clinical electrocardiology by reading this book, including expert review of the genetic and epidemiologic considerations, diagnostic and therapeutic modalities of the newly discovered clinical syndromes and electrocardiographic phenomena, and their correlation with the most recent advances in the basic science.
650 0 _aMedicine.
650 0 _aInternal medicine.
650 0 _aCardiology.
650 0 _aNeurology.
650 0 _aEpidemiology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aCardiology.
650 2 4 _aEpidemiology.
650 2 4 _aNeurology.
650 2 4 _aInternal Medicine.
700 1 _aAntzelevitch, Charles.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781447148807
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4471-4881-4
912 _aZDB-2-SME
999 _c94723
_d94723