000			03733nam a22005295i 4500
001			978-1-4419-1688-4
003			DE-He213
005			20140220082802.0
007			cr nn 008mamaa
008			130327s2013 xxu| s |||| 0|eng d
020			_a9781441916884 _9978-1-4419-1688-4
024	7		_a10.1007/978-1-4419-1688-4 _2doi
050		4	_aQH441.5
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
072		7	_aSCI029000 _2bisacsh
082	0	4	_a611.01816 _223
100	1		_aGersen, Steven L. _eeditor.
245	1	4	_aThe Principles of Clinical Cytogenetics _h[electronic resource] / _cedited by Steven L. Gersen, Martha B. Keagle.
250			_a3rd ed. 2013.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aX, 569 p. 207 illus., 107 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aHistory of Clinical Cytogenetics -- DNA, Chromosomes, and Cell Division -- Human Chromosome Nomenclature: An Overview and Definition of Terms -- Basic Cytogenetics Laboratory Procedures -- The Essentials of Light Microscopy -- Quality Control & Quality Assurance -- Instrumentation in the Cytogenetics Laboratory -- Autosomal Aneuploidy -- Structural Chromosome Rearrangements -- Sex Chromosomes, Sex Chromosome Disorders, and Disorders of Sex Development -- The Cytogenetics of Infertility -- Prenatal Cytogenetics -- The Cytogenetics of Spontaneous Abortion -- Chromosome Instability -- The Cytogenetics of Hematologic Neoplasms -- The Cytogenetics of Solid Tumors -- Fluorescence in situ Hybridization (FISH) -- Microarray-Based Cytogenetics -- Fragile X: A Family of Disorders: Changing Phenotype and Molecular Genetics -- Genomic Imprinting and Uniparental Disomy -- Genetic Counseling.
520			_aIn this thoroughly revised and expanded third edition of the highly praised classic, The Principles of Clinical Cytogenetics, a panel of hands-on experts update their descriptions of the basic concepts and interpretations involved in chromosome analysis to include the many advances that have occurred in the field. Among the highlights are a full chapter devoted to advances in chromosome microarray, soon to become a standard of care in this field, as well as an update on chromosome nomenclature as reflected in ISCN 2009. Other features include an update on automation to reflect the current state of the art, an update on hematopoietic neoplasms to reflect the new WHO guidelines, and updates on all regulatory changes that have been implemented. Cutting edge and readily accessible, The Principles of Clinical Cytogenetics, Third Edition offers physicians who depend on the cytogenetics laboratory for the diagnosis of their patients, students in cytogenetics programs, graduate and medical students studying for board examinations, cytogenetics technologists, and cytogeneticists a clear understanding of what happens in the cytogenetics laboratory to facilitate accurate and timely diagnoses.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aHematology.
650		0	_aOncology.
650		0	_aPathology.
650	1	4	_aBiomedicine.
650	2	4	_aCytogenetics.
650	2	4	_aHuman Genetics.
650	2	4	_aPathology.
650	2	4	_aHematology.
650	2	4	_aOncology.
700	1		_aKeagle, Martha B. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781441916877
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4419-1688-4
912			_aZDB-2-SBL
999			_c94442 _d94442