000 03391nam a22005055i 4500
001 978-94-007-7624-1
003 DE-He213
005 20140220082532.0
007 cr nn 008mamaa
008 131029s2014 ne | s |||| 0|eng d
020 _a9789400776241
_9978-94-007-7624-1
024 7 _a10.1007/978-94-007-7624-1
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aBurkovski, Andreas.
_eeditor.
245 1 0 _aCorynebacterium diphtheriae and Related Toxigenic Species
_h[electronic resource] :
_bGenomics, Pathogenicity and Applications /
_cedited by Andreas Burkovski.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2014.
300 _aXVII, 293 p. 22 illus., 8 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aDiphtheria and Its Etiological Agents -- Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis - General Aspects -- Comparative Genomics and Pathogenicity Islands of Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis -- Corynephages: Infections of the Infectors -- Toxin Structure, Delivery and Action -- Iron Acquisition and Iron-Dependent Gene expression in Corynebacterium diphtheria -- Assembly and Function of Corynebacterium diphtheria -- Toxigenic Corynebacteria: Adhesion, Invasion and Host Response -- Detection Methods for Laboratory Diagnosis of Diphtheria -- Diphtheria Surveillance -- History of diphtheria Vaccine Development -- Antimicrobial Susceptibility and Treatment -- Sialidases of Corynebacteria and Their Biotechnological Application -- Molecular Genetic Tools for Research in Corynebacterium diphtheria -- Diphtheria Toxin Based Molecules as Therapeutic Approaches.
520 _aCorynebacterium diphtheriae is the classical etiological agent of diphtheria and the type strain of the genus Corynebacterium. While diphtheria of the respiratory tract became rare with the introduction of vaccination programs in industrialized countries, even today several thousand cases per year are reported to the World Health Organization. This shows that diphtheria is not completely eradicated and that reservoirs exist. The book summarizes the latest advances made in understanding C. diphtheriae and the closely related species Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Topics addressed are genomics of toxigenic corynebacteria, host-pathogen-interaction, detection, surveillance and treatment as well as application aspects.
650 0 _aMedicine.
650 0 _aMicrobiology.
650 0 _aMedical parasitology.
650 0 _aEpidemiology.
650 0 _aBacteriology.
650 0 _aMicrobial genetics.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aBacteriology.
650 2 4 _aEpidemiology.
650 2 4 _aParasitology.
650 2 4 _aMicrobial Genetics and Genomics.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400776234
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-7624-1
912 _aZDB-2-SBL
999 _c94083
_d94083