000 02787nam a22004935i 4500
001 978-3-642-40252-4
003 DE-He213
005 20140220082520.0
007 cr nn 008mamaa
008 131106s2014 gw | s |||| 0|eng d
020 _a9783642402524
_9978-3-642-40252-4
024 7 _a10.1007/978-3-642-40252-4
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aBoehm, Thomas.
_eeditor.
245 1 0 _aThymic Development and Selection of T Lymphocytes
_h[electronic resource] /
_cedited by Thomas Boehm, Yousuke Takahama.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aVII, 132 p. 11 illus., 9 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v373
505 0 _aDevelopment and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.-  Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.
520 _aThe thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aHuman physiology.
650 0 _aImmunology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aHuman Physiology.
650 2 4 _aCytogenetics.
700 1 _aTakahama, Yousuke.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642402517
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v373
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-40252-4
912 _aZDB-2-SBL
999 _c93403
_d93403