000 | 02787nam a22004935i 4500 | ||
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001 | 978-3-642-40252-4 | ||
003 | DE-He213 | ||
005 | 20140220082520.0 | ||
007 | cr nn 008mamaa | ||
008 | 131106s2014 gw | s |||| 0|eng d | ||
020 |
_a9783642402524 _9978-3-642-40252-4 |
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024 | 7 |
_a10.1007/978-3-642-40252-4 _2doi |
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050 | 4 | _aQR180-189.5 | |
072 | 7 |
_aMJCM _2bicssc |
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072 | 7 |
_aMED044000 _2bisacsh |
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082 | 0 | 4 |
_a616.079 _223 |
100 | 1 |
_aBoehm, Thomas. _eeditor. |
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245 | 1 | 0 |
_aThymic Development and Selection of T Lymphocytes _h[electronic resource] / _cedited by Thomas Boehm, Yousuke Takahama. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2014. |
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300 |
_aVII, 132 p. 11 illus., 9 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v373 |
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505 | 0 | _aDevelopment and Function of Cortical Thymic Epithelial Cells -- Mechanisms of Thymus Medulla Development And Function -- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction -- Trafficking to the Thymus -- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes. | |
520 | _aThe thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aHuman genetics. | |
650 | 0 | _aHuman physiology. | |
650 | 0 | _aImmunology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aImmunology. |
650 | 2 | 4 | _aHuman Physiology. |
650 | 2 | 4 | _aCytogenetics. |
700 | 1 |
_aTakahama, Yousuke. _eeditor. |
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710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783642402517 |
830 | 0 |
_aCurrent Topics in Microbiology and Immunology, _x0070-217X ; _v373 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-40252-4 |
912 | _aZDB-2-SBL | ||
999 |
_c93403 _d93403 |