000 02812nam a22004695i 4500
001 978-3-642-39968-8
003 DE-He213
005 20140220082520.0
007 cr nn 008mamaa
008 131004s2014 gw | s |||| 0|eng d
020 _a9783642399688
_9978-3-642-39968-8
024 7 _a10.1007/978-3-642-39968-8
_2doi
050 4 _aQR46
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9041
_223
100 1 _aMarinelli, Flavia.
_eeditor.
245 1 0 _aAntimicrobials
_h[electronic resource] :
_bNew and Old Molecules in the Fight Against Multi-resistant Bacteria /
_cedited by Flavia Marinelli, Olga Genilloud.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aVIII, 364 p. 71 illus., 10 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
520 _aReports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
650 0 _aMedicine.
650 0 _aMicrobiology.
650 0 _aDrug interactions.
650 0 _aEmerging infectious diseases.
650 1 4 _aBiomedicine.
650 2 4 _aMedical Microbiology.
650 2 4 _aDrug Resistance.
650 2 4 _aInfectious Diseases.
650 2 4 _aApplied Microbiology.
700 1 _aGenilloud, Olga.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642399671
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-39968-8
912 _aZDB-2-SBL
999 _c93377
_d93377