000			03413nam a22005295i 4500
001			978-3-540-75863-1
003			DE-He213
005			20140220082515.0
007			cr nn 008mamaa
008			131211s2014 gw | s |||| 0|eng d
020			_a9783540758631 _9978-3-540-75863-1
024	7		_a10.1007/978-3-540-75863-1 _2doi
050		4	_aR895-920
072		7	_aMMPH _2bicssc
072		7	_aMMP _2bicssc
072		7	_aMED008000 _2bisacsh
082	0	4	_a616.0757 _223
100	1		_aRubin, Philip. _eeditor.
245	1	0	_aALERT • Adverse Late Effects of Cancer Treatment _h[electronic resource] : _bVolume 2: Normal Tissue Specific Sites and Systems / _cedited by Philip Rubin, Louis S. Constine, Lawrence B. Marks.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2014.
300			_aXX, 700 p. 196 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMedical Radiology, _x0942-5373
505	0		_aCentral and Peripheral Nervous System -- Special Sensory Organ Systems -- Upper Digestive System -- Upper Respiratory System -- Respiratory System -- Cardiovascular System -- Digestive System -- Major Digestive Glands -- Genitourinary System -- Male Genital System -- Female Genital System -- Integument (Appendages) System -- Musculoskeletal System -- Hematopoetic System -- Lymphoid System -- Endocrine System.
520			_aThe literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT – Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables.
650		0	_aMedicine.
650		0	_aRadiology, Medical.
650		0	_aRadiotherapy.
650		0	_aOncology.
650	1	4	_aMedicine & Public Health.
650	2	4	_aImaging / Radiology.
650	2	4	_aDiagnostic Radiology.
650	2	4	_aRadiotherapy.
650	2	4	_aOncology.
700	1		_aConstine, Louis S. _eeditor.
700	1		_aMarks, Lawrence B. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783540758624
830		0	_aMedical Radiology, _x0942-5373
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-540-75863-1
912			_aZDB-2-SME
999			_c93101 _d93101