000 | 02834nam a22004815i 4500 | ||
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001 | 978-3-319-02159-1 | ||
003 | DE-He213 | ||
005 | 20140220082510.0 | ||
007 | cr nn 008mamaa | ||
008 | 131031s2014 gw | s |||| 0|eng d | ||
020 |
_a9783319021591 _9978-3-319-02159-1 |
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024 | 7 |
_a10.1007/978-3-319-02159-1 _2doi |
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050 | 4 | _aQD71-142 | |
072 | 7 |
_aPNF _2bicssc |
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072 | 7 |
_aSCI013010 _2bisacsh |
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082 | 0 | 4 |
_a543 _223 |
100 | 1 |
_aSharp, Thomas Harry. _eauthor. |
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245 | 1 | 0 |
_aBiomolecular Imaging at High Spatial and Temporal Resolution In Vitro and In Vivo _h[electronic resource] / _cby Thomas Harry Sharp. |
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2014. |
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300 |
_aXVIII, 150 p. 85 illus., 55 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
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505 | 0 | _aBiomolecules & Microscopy -- Materials and Methods -- Experimental Methods -- Imaging Methods -- Experimental Results -- Towards an Atomistic Structure of a De Novo Designed Peptide Fibre -- Developing Novel Probes for Correlative Light Electron Microscopy. | |
520 | _aAs part of a collaboration between two different groups in chemistry and biochemistry, Thom Sharp presents here his thesis work on the development of new methods for cryoelectron microscopy. Throughout his PhD, Thom had to master a whole range of techniques including modelling, molecular biology and microscopy. Using these skills to tackle an outstanding problem, the pursuit of high-resolution structures of peptide-based materials, Thom highlights in this thesis his newly developed methods for analysing and processing this particular type of electron microscopy data. This thesis gives the first molecular description of a de-novo designed peptide-based material. In general, this research will have a huge impact on the peptide assembly field, and also in electron microscopy as it introduces new methods and approaches, all of which are Thom's inventions and are described in this thesis. | ||
650 | 0 | _aChemistry. | |
650 | 0 | _aAnalytical biochemistry. | |
650 | 0 | _aMicroscopy. | |
650 | 0 | _aBiomaterials. | |
650 | 1 | 4 | _aChemistry. |
650 | 2 | 4 | _aAnalytical Chemistry. |
650 | 2 | 4 | _aBiological Microscopy. |
650 | 2 | 4 | _aBiomaterials. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783319021584 |
830 | 0 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-02159-1 |
912 | _aZDB-2-CMS | ||
999 |
_c92820 _d92820 |