000 03531nam a22004935i 4500
001 978-3-0348-0726-5
003 DE-He213
005 20140220082506.0
007 cr nn 008mamaa
008 131108s2014 sz | s |||| 0|eng d
020 _a9783034807265
_9978-3-0348-0726-5
024 7 _a10.1007/978-3-0348-0726-5
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aMartin, Stefan F.
_eeditor.
245 1 0 _aT Lymphocytes as Tools in Diagnostics and Immunotoxicology
_h[electronic resource] /
_cedited by Stefan F. Martin.
264 1 _aBasel :
_bSpringer Basel :
_bImprint: Springer,
_c2014.
300 _aVI, 184 p. 27 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aExperientia Supplementum,
_x1023-294X ;
_v104
505 0 _aThe use of T cells in Hazard Characterization of Chemical and Drug Allergens and integration in testing strategies -- Activation of the TCR complex by peptide-MHC and superantigens -- Activation of the TCR complex by small chemical compounds -- T Cell Responses to Contact Allergens -- Contact hypersensitivity: Quantitative aspects, susceptibility and risk factors -- Tools and methods for identification and analysis of rare antigen-specific T lymphocytes -- Human T cell priming assay. Depletion of peripheral blood lymphocytes in CD25+ cells improves the in vitro detection of weak allergen-specific T cells -- Correlation of contact sensitizer potency with T cell frequency and TCR repertoire diversity -- On the role of co-inhibitory molecules in dendritic cell – T helper cell co-culture assays aimed to detect chemical induced contact allergy -- T cell responses to drugs and drug metabolites -- Hypersensitivity reactions to betalactams.
520 _aThis book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMedical laboratories.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aImmunology.
650 2 4 _aLaboratory Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783034807258
830 0 _aExperientia Supplementum,
_x1023-294X ;
_v104
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0348-0726-5
912 _aZDB-2-SBL
999 _c92449
_d92449