000			03065nam a22004935i 4500
001			978-1-4614-9545-1
003			DE-He213
005			20140220082505.0
007			cr nn 008mamaa
008			140107s2014 xxu| s |||| 0|eng d
020			_a9781461495451 _9978-1-4614-9545-1
024	7		_a10.1007/978-1-4614-9545-1 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aKanner, Steven. _eeditor.
245	1	0	_aTumor Metabolome Targeting and Drug Development _h[electronic resource] / _cedited by Steven Kanner.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014.
300			_aVIII, 198 p. 22 illus., 12 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Drug Discovery and Development, _x2196-9906
505	0		_aTumor cell metabolic reprogramming and drug targeting -- Cancer metabolism: a nexus of matter, energy and reactive oxygen species -- Regulating mitochondrial respiration in cancer -- Regulation of cancer cell metabolism by hypoxia -- Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs -- Modulating autophagy and the “reverse Warburg effect” -- Metabolic adaptation in reprogrammed cancer cells -- Index.
520			_aIn this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.  The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate.  However, the metabolism of malignant cells generally varies from that of normal cells.  These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options  Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650		0	_aMetabolism.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aMetabolomics.
650	2	4	_aMolecular Medicine.
650	2	4	_aPharmacology/Toxicology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461495444
830		0	_aCancer Drug Discovery and Development, _x2196-9906
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-9545-1
912			_aZDB-2-SME
999			_c92392 _d92392