000 | 03570nam a22004815i 4500 | ||
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001 | 978-1-4614-9443-0 | ||
003 | DE-He213 | ||
005 | 20140220082505.0 | ||
007 | cr nn 008mamaa | ||
008 | 131123s2014 xxu| s |||| 0|eng d | ||
020 |
_a9781461494430 _9978-1-4614-9443-0 |
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024 | 7 |
_a10.1007/978-1-4614-9443-0 _2doi |
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050 | 4 | _aQA276-280 | |
072 | 7 |
_aPBT _2bicssc |
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072 | 7 |
_aMBNS _2bicssc |
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072 | 7 |
_aMED090000 _2bisacsh |
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082 | 0 | 4 |
_a519.5 _223 |
100 | 1 |
_aStram, Daniel O. _eauthor. |
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245 | 1 | 0 |
_aDesign, Analysis, and Interpretation of Genome-Wide Association Scans _h[electronic resource] / _cby Daniel O. Stram. |
264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014. |
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300 |
_aXV, 334 p. 39 illus. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aStatistics for Biology and Health, _x1431-8776 |
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505 | 0 | _aIntroduction to Genome-Wide Association Studies -- Topics of Quantitative Genetics -- An Introduction to Association Studies -- Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation -- Haplotype Imputation for Association Analysis -- SNP Imputation for Association Studies -- Design of Large-scale Genetic Association Studies, Sample Size and Power -- Post-GWAS Analyses. | |
520 | _aThis book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects. | ||
650 | 0 | _aStatistics. | |
650 | 0 | _aHuman genetics. | |
650 | 0 | _aMathematical statistics. | |
650 | 1 | 4 | _aStatistics. |
650 | 2 | 4 | _aStatistics for Life Sciences, Medicine, Health Sciences. |
650 | 2 | 4 | _aHuman Genetics. |
650 | 2 | 4 | _aStatistical Theory and Methods. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9781461494423 |
830 | 0 |
_aStatistics for Biology and Health, _x1431-8776 |
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856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-9443-0 |
912 | _aZDB-2-SMA | ||
999 |
_c92378 _d92378 |