000			03831nam a22005175i 4500
001			978-1-4614-8915-3
003			DE-He213
005			20140220082503.0
007			cr nn 008mamaa
008			131108s2014 xxu| s |||| 0|eng d
020			_a9781461489153 _9978-1-4614-8915-3
024	7		_a10.1007/978-1-4614-8915-3 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aMED057000 _2bisacsh
082	0	4	_a612.8 _223
100	1		_aChen, Jun. _eeditor.
245	1	0	_aImmunological Mechanisms and Therapies in Brain Injuries and Stroke _h[electronic resource] / _cedited by Jun Chen, Xiaoming Hu, Mary Stenzel-Poore, John H. Zhang.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014.
300			_aX, 386 p. 34 illus., 21 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Series in Translational Stroke Research ; _v6
505	0		_aOld dogmas, surprising complexities, and novel therapeutic targets -- The critical roles of immune cells in acute brain injuries -- Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte-Endothelial Interactions -- Immune Cell-Derived Free Radicals in Acute Brain Injury -- The complement cascade in acute brain injury -- Matrix Metalloproteinases as an Inflammatory Mediator in the Neurovascular Unit -- Toll-Like Receptors in Ischemic Stroke and other Acute Brain Injuries -- Ion Transporters in Microglial Function: New therapeutic targets for neuroinflammation in ischemic stroke? -- Inflammation After Acute Brain Injuries Affects the Developing Brain Differently than the Adult Brain -- Systemic Immune Responses after Experimental Stroke -- Infectious Burden and Risk of Stroke -- Inflammatory Biomarkers in Patients with Acute Brain Injuries -- In vivo Imaging of Neuroinflammation in Acute Brain Injury -- Inflammation as a therapeutic target after subarachnoid hemorrhage: advances and challenges -- Minocycline, a Tetracycline Derivative, as a Potential Protective Agent for Acute Stroke -- Tolerization to Brain and Vascular Antigens: Targeting Autoimmunity after Acute Brain Injuries and Preventing Stroke -- The Role of PPARg in Stroke -- CD36: an inflammatory mediator in acute brain injury -- Cool Down the Inflammation:  Hypothermia as a Therapeutic Strategy for Acute Brain Injuries -- Index.
520			_aRecent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system.  This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.
650		0	_aMedicine.
650		0	_aNeurosciences.
650		0	_aNeurology.
650		0	_aNeurobiology.
650	1	4	_aBiomedicine.
650	2	4	_aNeurosciences.
650	2	4	_aNeurology.
650	2	4	_aNeurobiology.
700	1		_aHu, Xiaoming. _eeditor.
700	1		_aStenzel-Poore, Mary. _eeditor.
700	1		_aZhang, John H. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461489146
830		0	_aSpringer Series in Translational Stroke Research ; _v6
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-8915-3
912			_aZDB-2-SME
999			_c92278 _d92278