000 03535nam a22004935i 4500
001 978-90-481-9060-7
003 DE-He213
005 20140220084602.0
007 cr nn 008mamaa
008 100812s2010 ne | s |||| 0|eng d
020 _a9789048190607
_9978-90-481-9060-7
024 7 _a10.1007/978-90-481-9060-7
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aLeung, Po Sing.
_eauthor.
245 1 4 _aThe Renin-Angiotensin System: Current Research Progress in The Pancreas
_h[electronic resource] :
_bThe RAS in the Pancreas /
_cby Po Sing Leung.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2010.
300 _aXVI, 208 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v690
505 0 _aThe Pancreas -- Overview of the Pancreas -- Physiology of the Pancreas -- Common Pancreatic Disease -- The Renin-Angiotensin System (RAS) -- Circulating RAS -- Local RAS -- Pancreatic RAS -- Research Progress Of The Ras In Pancreas -- Basic Techniques for Pancreatic Research -- Current Research of the RAS in Diabetes Mellitus -- Current Research Concerning the RAS in Pancreatic Stem Cells -- Current Research of the RAS in Pancreatitis and Pancreatic Cancer.
520 _aThe human pancreas has vital roles in the regulation of glucose homeostasis and digestion and its dysfunction leads to pancreatic disease as diabetes and pancreatitis. Recent researches have highlighted the novel roles of a local renin-angiotensin system (RAS) in the pancreas and its clinical relevances; its inapprporiate activation leads to pancreatic endocrine and exocrine disease, notably type 2 diabetes. As such, manipulation of the overactive RAS may improve pancreatic islet cell function, cell mass and insulin sensitivity, as well as enhancing the growth and differentiation of pancreatic stem cells. Blockade of the RAS may be protective against pancreatitis and pancreatic cancer. The research outcome of current progress on the RAS in the pancreas should provide an alternative approach to preventing and treating, as well as curing pancreatic disease. This book discusses the progress of research on the renin-angiotensin system in the pancreas from the science to the bedside, providing a timely review of this expanding area. It consists of ten interrelated chapters covering subjects as: – Structure, physiology and disease of the pancreas – Biochemistry and physiology of the pancreatic renin-angiotensin system – RAS in diabetes, stem cells and pancreatitis This book is of special value to basic and clinical scientists, clinicians, graduate students, as well as novices in this field.  
650 0 _aMedicine.
650 0 _aHuman physiology.
650 0 _aDiabetes.
650 0 _aGastroenterology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aHuman Physiology.
650 2 4 _aDiabetes.
650 2 4 _aGastroenterology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048190591
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v690
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-9060-7
912 _aZDB-2-SBL
999 _c113581
_d113581