000 04023nam a22004935i 4500
001 978-90-481-3415-1
003 DE-He213
005 20140220084558.0
007 cr nn 008mamaa
008 100301s2010 ne | s |||| 0|eng d
020 _a9789048134151
_9978-90-481-3415-1
024 7 _a10.1007/978-90-481-3415-1
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aCecconi, Francesco.
_eeditor.
245 1 0 _aApoptosome
_h[electronic resource] :
_bAn up-and-coming therapeutical tool /
_cedited by Francesco Cecconi, Marcello D'Amelio.
264 1 _aDordrecht :
_bSpringer Netherlands,
_c2010.
300 _bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPhysiological and Pathological Role of Apoptosis -- Apoptosome Structure and Regulation -- Chemical Regulation of the Apoptosome: New Alternative Treatments for Cancer -- Molecules That Bind a Central Protein Component of the Apoptosome, Apaf-1, and Modulate Its Activity -- Regulation of Cell Death and Survival by RNA Interference – The Roles of miRNA and siRNA -- Beneficial Role of Taurine Against Myocardial Apoptosis During Ischemic Injury -- BAG3 Protein: Role in Some Neoplastic Cell Types and Identification as a Candidate Target for Therapy -- Targeting Survivin in Cancer Therapy: Pre-clinical Studies -- Hsp70 and Hsp27: Emerging Targets in Cancer Therapy -- Role of the RNA-Binding Protein HuR in Apoptosis and Apoptosome Function -- Acetylcholinesterase as a Pharmacological Target in Cancer Research -- Putative Role of HCA66, A New Apaf-1 Interacting Protein, in the Physiopathology of NF1 Microdeletion Syndrome Patients -- Cristae Remodeling and Mitochondrial Fragmentation: A Checkpoint for Cytochrome c Release and Apoptosis? -- Apoptosome Pharmacological Manipulation: From Current Developments in the Laboratory to Clinical Implications -- The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury -- Targeting Survivin in Cancer Therapy: Clinical Considerations.
520 _a"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome. The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis. This book will be a valuable resource for researchers investigating the role of apoptosome-dependent cell death in cancer and other diseases, for researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance and for physicians using chemotherapeutic agents. Additionally, this book will be an important educational source for PhD students and MD students specializing in molecular and cell biology, and to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of programmed cell death.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aCell Biology.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aApoptosis.
700 1 _aD'Amelio, Marcello.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789048134144
856 4 0 _uhttp://dx.doi.org/10.1007/978-90-481-3415-1
912 _aZDB-2-SBL
999 _c113344
_d113344