000			03885nam a22005535i 4500
001			978-4-431-09425-8
003			DE-He213
005			20140220084553.0
007			cr nn 008mamaa
008			100301s2010 ja | s |||| 0|eng d
020			_a9784431094258 _9978-4-431-09425-8
024	7		_a10.1007/978-4-431-09425-8 _2doi
050		4	_aQH201-278.5
072		7	_aPS _2bicssc
072		7	_aPDND _2bicssc
072		7	_aSCI086000 _2bisacsh
072		7	_aSCI023000 _2bisacsh
082	0	4	_a570.282 _223
100	1		_aSetou, Mitsutoshi. _eeditor.
245	1	0	_aImaging Mass Spectrometry _h[electronic resource] : _bProtocols for Mass Microscopy / _cedited by Mitsutoshi Setou.
264		1	_aTokyo : _bSpringer Japan : _bImprint: Springer, _c2010.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aInnovation of Imaging Mass Spectrometry -- IMS as an Historical Innovation -- Planning the Sample Preparation -- Guide to Planning the Sample Preparation Step -- Sample Preparation -- Animal Care and Tissue Sample Extraction for IMS -- Preparing Biological Tissue Sections for Imaging Mass Spectrometry -- Matrix Choice -- Methods of Matrix Application -- Matrix Application with ImagePrep -- Instrumental Operation for IMS -- Method of Operating AXIMA-QIT as Imaging Instrument -- Analysis of Measurement Data -- Ion Image Reconstruction Using BioMap Software -- Statistical Procedure for IMS Data Analysis -- Statistical Analysis of IMS Dataset with ClinproTool Software -- Applications of MALDI-IMS -- Imaging of Cultured Cells by Mass Spectrometry -- TLC-Blot-MALDI-IMS -- IMS Applications Provided by Manufacturers -- Applied Biosystems -- Bruker Daltonics -- Imaging and Molecular Identification of Biomolecules on Tissue Sections with AXIMA-QIT: Shimadzu Corporation -- MALDI Imaging with Ion-Mobility MS: Waters Corporation -- Comparison of SIMS and MALDI for Mass Spectrometric Imaging -- Comparison of SIMS and MALDI for Mass Spectrometric Imaging.
520			_aAddressing the widespread need for a practical guide to imaging mass spectrometry (IMS), this book presents the protocols of IMS technology. As that technology expands, research groups around the world continue its development. Pharmaceutical companies are using IMS for drug analyses to study pharmacokinetics and medical properties of drugs. Drug research and disease-related biomarker screening are experiencing greater use of this technology, with a concurrent increase in the number of researchers in academia and industry interested in wider applications of IMS. Intended for beginners or those with limited experience with IMS technology, this book provides practical details and instructions needed for immediate know-how, including the preparation of animal tissue samples, the application of a matrix, instrumental operations, and data analysis, among others. By describing the foundations of IMS, this volume contributes to the ongoing development of the field and to progress in human health.
650		0	_aLife sciences.
650		0	_aToxicology.
650		0	_aMass spectrometry.
650		0	_aRadiology, Medical.
650		0	_aCytology.
650		0	_aMicroscopy.
650		0	_aCytology _xResearch_xMethodology.
650	1	4	_aLife Sciences.
650	2	4	_aBiological Microscopy.
650	2	4	_aCell Biology.
650	2	4	_aBiological Techniques.
650	2	4	_aImaging / Radiology.
650	2	4	_aMass Spectrometry.
650	2	4	_aPharmacology/Toxicology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9784431094241
856	4	0	_uhttp://dx.doi.org/10.1007/978-4-431-09425-8
912			_aZDB-2-SBL
999			_c113071 _d113071