000 | 03699nam a22005055i 4500 | ||
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001 | 978-3-642-15603-8 | ||
003 | DE-He213 | ||
005 | 20140220084546.0 | ||
007 | cr nn 008mamaa | ||
008 | 101001s2010 gw | s |||| 0|eng d | ||
020 |
_a9783642156038 _9978-3-642-15603-8 |
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024 | 7 |
_a10.1007/978-3-642-15603-8 _2doi |
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050 | 4 | _aQA76.9.M35 | |
072 | 7 |
_aGPFC _2bicssc |
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072 | 7 |
_aTEC000000 _2bisacsh |
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082 | 0 | 4 |
_a620 _223 |
100 | 1 |
_aPatel, Manish. _eauthor. |
|
245 | 1 | 4 |
_aThe Role of Model Integration in Complex Systems Modelling _h[electronic resource] : _bAn Example from Cancer Biology / _cby Manish Patel, Sylvia Nagl. |
264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2010. |
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300 |
_a176p. 36 illus. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aUnderstanding Complex Systems, _x1860-0832 |
|
505 | 0 | _aNature to Numbers: Complex Systems Modelling of Cancer -- Coping with Complexity: Modelling of Complex Systems -- Complexity and Model Integration: Formalisations -- Novel Strategies for Integrating Models into Systems-Level Simulations -- Experiments in Model Integration -- Discussion. | |
520 | _aModel integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value. | ||
650 | 0 | _aEngineering. | |
650 | 0 | _aOncology. | |
650 | 0 | _aBiological models. | |
650 | 0 | _aPhysics. | |
650 | 1 | 4 | _aEngineering. |
650 | 2 | 4 | _aComplexity. |
650 | 2 | 4 | _aStatistical Physics, Dynamical Systems and Complexity. |
650 | 2 | 4 | _aSystems Biology. |
650 | 2 | 4 | _aCancer Research. |
700 | 1 |
_aNagl, Sylvia. _eauthor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783642156021 |
830 | 0 |
_aUnderstanding Complex Systems, _x1860-0832 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-15603-8 |
912 | _aZDB-2-PHA | ||
999 |
_c112677 _d112677 |