000			03346nam a22004695i 4500
001			978-3-642-12617-8
003			DE-He213
005			20140220084535.0
007			cr nn 008mamaa
008			100722s2010 gw | s |||| 0|eng d
020			_a9783642126178 _9978-3-642-12617-8
024	7		_a10.1007/978-3-642-12617-8 _2doi
050		4	_aQH573-671
072		7	_aPSF _2bicssc
072		7	_aSCI049000 _2bisacsh
082	0	4	_a571.6 _223
100	1		_aKikuchi, Yo. _eeditor.
245	1	0	_aExtracellular Nucleic Acids _h[electronic resource] / _cedited by Yo Kikuchi, Elena Y. Rykova.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2010.
300			_aX, 220p. 34 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aNucleic Acids and Molecular Biology, _x0933-1891 ; _v25
505	0		_aExtracellular DNA as Matrix Component in Microbial Biofilms -- Gene Transfer Agents and Defective Bacteriophages as Sources of Extracellular Prokaryotic DNA -- Roles of Extracellular DNA in Bacterial Ecosystem -- Stable Extracellular DNA: A Novel Substrate for Genetic Engineering that Mimics Horizontal Gene Transfer in Nature -- Extracellular Nucleic Acids of the Marine Phototrophic Bacterium Rhodovulum sulfidophilum and Related Bacteria: Physiology and Biotechnology -- Systemic RNAi in C. elegans from the Viewpoint of RNA as Extracellular Signals -- Circulating Nucleic Acids in Health and Disease -- Circulating MicroRNAs in Cancer -- Biology and Diagnostic Applications of Cell-Free Fetal Nucleic Acids in Maternal Plasma -- The Biology of Circulating Nucleic Acids in Plasma and Serum (CNAPS) -- Modulation and Regulation of Gene Expression by CpG Oligonucleotides -- Immune Recognition of Nucleic Acids and Their Metabolites.
520			_aExtracellular nucleic acids have recently emerged as important players in the fields of biology and the medical sciences. In the last several years, extracellular nucleic acids have been shown to be involved in not only microbial evolution as genetic elements but also to have structural roles in bacterial communities, such as biofilms. Circulating DNA and RNA have been found in human blood and expected to be useful as non-invasive markers for the diagnosis of several diseases. In addition, extracellular nucleic acids have attracted attention as active modulators of the immune system of higher organisms, including humans. This book covers nearly all of the newly developing fields related to extracellular nucleic acids, including those of basic biology, ecology and the medical sciences, and provides readers with the latest knowledge on them.
650		0	_aLife sciences.
650		0	_aBiochemistry.
650		0	_aCytology.
650	1	4	_aLife Sciences.
650	2	4	_aCell Biology.
650	2	4	_aBiochemistry, general.
700	1		_aRykova, Elena Y. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642126161
830		0	_aNucleic Acids and Molecular Biology, _x0933-1891 ; _v25
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-12617-8
912			_aZDB-2-SBL
999			_c112110 _d112110