000 03889nam a22005295i 4500
001 978-3-642-12168-5
003 DE-He213
005 20140220084533.0
007 cr nn 008mamaa
008 100907s2010 gw | s |||| 0|eng d
020 _a9783642121685
_9978-3-642-12168-5
024 7 _a10.1007/978-3-642-12168-5
_2doi
050 4 _aQH506
072 7 _aMBGR
_2bicssc
072 7 _aPSD
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aMED067000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aErdmann, Volker A.
_eeditor.
245 1 0 _aRNA Technologies and Their Applications
_h[electronic resource] /
_cedited by Volker A. Erdmann, Jan Barciszewski.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2010.
300 _aXVI, 452 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aRNA Technologies
505 0 _aThe Key Features of RNA Silencing -- Selected Strategies for the Delivery of siRNA In Vitro and In Vivo -- RNAi Suppression and Its Application -- Strategies to Prevent siRNA-Triggered Cellular Toxicity -- RNAi in Malignant Brain Tumors: Relevance to Molecular and Translational Research -- Silencing Huntington’s Disease Gene with RNAi -- Application of Dicer-Substrate siRNA in Pain Research -- RNAi Treatment of HIV-1 Infection -- Application of RNA Interference to Treat Conditions Associated with Dysregulation of Transient Receptor Potential Vanilloid 1 Channel -- Harnessing RNAi-Based Functional Genomics to Unravel the Molecular Complexity Underlying Skin Pigment Variation -- mRNA Structure and its Effects on Posttranscriptional Gene Silencing -- Antisense RNA-Mediated Regulation of the p53 Tumor Suppressor -- Antisense Oligonucleotides: Insights from Preclinical Studies and Clinical Trials -- What can the New Hammerhead Ribozyme Structures Teach us About Design? -- microRNA Biogenesis and its Impact on RNA Interference -- MicroRNAs in Epithelial Antimicrobial Immunity -- Emerging Roles of Long Noncoding RNAs in Gene Expression and Intracellular Organization -- Noncoding RNAs as Therapeutic Targets -- Noncoding RNAs at H19/IGF2 Locus: Role in Imprinting, Gene Expression, and Associated Pathologies.
520 _aRNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aNucleic acids.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aMolecular Medicine.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aHuman Genetics.
650 2 4 _aCell Biology.
700 1 _aBarciszewski, Jan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642121678
830 0 _aRNA Technologies
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-12168-5
912 _aZDB-2-SBL
999 _c112012
_d112012