000			03060nam a22004215i 4500
001			978-3-642-03733-7
003			DE-He213
005			20140220084525.0
007			cr nn 008mamaa
008			100301s2010 gw | s |||| 0|eng d
020			_a9783642037337 _9978-3-642-03733-7
024	7		_a10.1007/978-3-642-03733-7 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aAlibardi, Lorenzo. _eauthor.
245	1	0	_aMorphological and Cellular Aspects of Tail and Limb Regeneration in Lizards _h[electronic resource] : _bA Model System With Implications for Tissue Regeneration in Mammals / _cby Lorenzo Alibardi.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg, _c2010.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Anatomy, Embryology and Cell Biology, _x0301-5556 ; _v207
505	0		_aRegeneration in Reptiles and Its Position Among Vertebrates -- Tail Regeneration: Ultrastructural and Cytological Aspects -- Limb Regeneration: Ultrastructural and Cytological Aspects -- Conclusion and Perspectives: Implications for Human Regeneration.
520			_aThe present review deals with the analysis of the cytological processess occurring during tissue regeneration in the tail and limb of lizards. These reptiles are considered as a model to understand the process of tissue regeneration in all amniotes. The review begins with some evolutive considerations on the origin of tail regeneration in comparison to the failure of limb regeneration, a unique case among amniotes. The formation of the tail in the embryo and the possible accumulation of stem cells in autotomous planes of the tail are discussed. The histological and ultrastructural processess occuring during blastema formation and tail regeneration and during limb cicatrization are presented. The comparison stresses the scarse to absent inflammatory reaction present in the tail vs the massive inflammatory response in the limb leading to scarring. In fact the experimental induction of a strong inflammation in the tail also leads to scarring. The importance of the nervous system in stimulating tail regeneration in lizards is emphasized. The presence of growth factors and extracellular matrix proteins during wound healing of the tail and limb is introduced. The review concludes stressing the importance of the lizard model of tissue regeneration for medical studies and applications.
650		0	_aMedicine.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642037320
830		0	_aAdvances in Anatomy, Embryology and Cell Biology, _x0301-5556 ; _v207
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-03733-7
912			_aZDB-2-SBL
999			_c111534 _d111534