000 03954nam a22005415i 4500
001 978-3-642-00150-5
003 DE-He213
005 20140220084521.0
007 cr nn 008mamaa
008 100301s2010 gw | s |||| 0|eng d
020 _a9783642001505
_9978-3-642-00150-5
024 7 _a10.1007/978-3-642-00150-5
_2doi
050 4 _aRD1-811
072 7 _aMNC
_2bicssc
072 7 _aMED085000
_2bisacsh
082 0 4 _a617
_223
100 1 _aDufour, Jean-Francois.
_eeditor.
245 1 0 _aSignaling Pathways in Liver Diseases
_h[electronic resource] /
_cedited by Jean-Francois Dufour, Pierre-Alain Clavien.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg,
_c2010.
300 _aVIII, 578 p. 41 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aThe Cell Types and the Matrix -- Hepatocytes -- Signaling Pathways in Biliary Epithelial Cells -- Stellate Cells -- Signaling Pathways in Liver Diseases Kupffer Cells -- Hepatic Sinusoidal Endothelial Cells -- Extracellular Matrix -- Platelets: A New Cell Type in Liver Physiology -- Immune Cell Communication and Signaling Systems in Liver Disease -- The Pathways -- Toll-Like Receptors -- TNF/TNF Receptors -- Fas/FasL -- Interferon Signaling -- NF-?B -- JNKs in liver diseases -- Insulin Pathway -- Role of PKB/Akt in Liver Diseases -- Targeting mTOR Signaling Pathways in Liver Disease -- AMP-Activated Protein Kinase in Liver -- ER Stress Signaling in Hepatic Injury -- PPAR?, A Key Regulator of Hepatic Energy Homeostasis in Health and Disease -- Bile Acids and Their Receptors -- Signaling Pathways in Liver Diseases: PXR and CAR -- p53 -- The MYC Network and Cancer -- The WNT/?-Catenin Pathway -- Sonic Hedgehog Pathway -- Hypoxia-Inducible Factor-1 Signaling System -- VEGF Signaling -- Apoptosis and Mitochondria -- Calcium Signaling -- HBV Signaling -- Hepatitis C Virus and Insulin Signaling -- MicroRNAs -- Hepatic Clocks.
520 _aSignaling Pathways in Liver Diseases, 2nd edition focuses on signaling pathways which are particularly important in liver diseases. Recent progress brought hepatology to new frontiers. The increasing frequency of surgery on steatotic and cirrhotic liver obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations and how they can be influenced. Better comprehension of the cellular mechanisms participating in liver regeneration, hepato-cellular apoptosis and ischemia/reperfusion inquiry is mirrored by a dramatic increase in complexity. The number and scope of publications is intimidating and difficult for busy individuals to extract a coherent framework. This book will serve as a source of information facilitating the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets for novel therapeutic strategies. It will furthermore stimulate more research and lead to better exchange between the laboratory, the clinical ward and the operation room.
650 0 _aMedicine.
650 0 _aInternal medicine.
650 0 _aGastroenterology.
650 0 _aClinical medicine.
650 0 _aSurgery.
650 0 _aEndoscopic surgery.
650 0 _aTransplantation of organs, tissues, etc.
650 1 4 _aMedicine & Public Health.
650 2 4 _aGeneral Surgery.
650 2 4 _aHepatology.
650 2 4 _aGastroenterology.
650 2 4 _aInternal Medicine.
650 2 4 _aMinimally Invasive Surgery.
650 2 4 _aTransplant Surgery.
700 1 _aClavien, Pierre-Alain.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642001499
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-00150-5
912 _aZDB-2-SME
999 _c111305
_d111305