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001 978-3-0346-0228-0
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005 20140220084518.0
007 cr nn 008mamaa
008 100825s2010 sz | s |||| 0|eng d
020 _a9783034602280
_9978-3-0346-0228-0
024 7 _a10.1007/978-3-0346-0228-0
_2doi
050 4 _aQP351-495
072 7 _aPSAN
_2bicssc
072 7 _aSCI070000
_2bisacsh
072 7 _aMED057000
_2bisacsh
082 0 4 _a573.8
_223
100 1 _aHökfelt, Tomas.
_eeditor.
245 1 0 _aGalanin
_h[electronic resource] /
_cedited by Tomas Hökfelt.
264 1 _aBasel :
_bSpringer Basel :
_bImprint: Springer,
_c2010.
300 _aX, 286 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aExperientia Supplementum,
_x1023-294X ;
_v102
505 0 _aGalanin: A Multitalented Neuropeptide -- Galanin, Galanin Receptors, and Drug Targets -- Galanin Acts as a Trophic Factor to the Central and Peripheral Nervous Systems -- Galanin and Spinal Pain Mechanisms: Past, Present, and Future -- Galanin Family of Peptides in Skin Function -- Galanin in Glia: Expression and Potential Roles in the CNS -- Galanin and the Neuroendocrine Axes -- Galanin and Consummatory Behavior: Special Relationship with Dietary Fat, Alcohol and Circulating Lipids -- Neurochemical Modulation of Central Cardiovascular Control: The Integrative Role of Galanin -- Galanin Impairs Cognitive Abilities in Rodents: Relevance to Alzheimer’s Disease -- Neuroprotective Role for Galanin in Alzheimer’s Disease -- Galanin, Galanin Receptor Subtypes and Depression-Like Behaviour -- Galanin and Epilepsy -- Galanin and Addiction -- Galanin Systems and Ischemia: Peptide and Receptor Plasticity in Neurons and Oligodendroglial Precursors -- The Galanin System in Cancer -- Galanin Systems in Non-mammalian Vertebrates with Special Focus on Fishes -- Galanin-Like Peptide: Neural Regulator of Energy Homeostasis and Reproduction.
520 _aGalanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and trophic factor, and is involved in a number of physiological processes such as hormone secretion, cardiovascular mechanisms, feeding and cognition. This peptide may also be of significance for a number of pathological processes/disorders including pain, depression, Alzheimer's disease, epilepsy, addiction and cancer. This wide diversity of actions is mediated by three galanin receptor subtypes. The studies reviewed in this volume give a fairly complete overview of the spectrum of the biological actions and functions of galanin and its receptors and on possible therapeutic applications in a number of pathological conditions.
650 0 _aLife sciences.
650 0 _aNeurobiology.
650 1 4 _aLife Sciences.
650 2 4 _aNeurobiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783034602273
830 0 _aExperientia Supplementum,
_x1023-294X ;
_v102
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0346-0228-0
912 _aZDB-2-SBL
999 _c111101
_d111101