000 04550nam a22004575i 4500
001 978-1-60761-543-9
003 DE-He213
005 20140220084513.0
007 cr nn 008mamaa
008 100623s2010 xxu| s |||| 0|eng d
020 _a9781607615439
_9978-1-60761-543-9
024 7 _a10.1007/978-1-60761-543-9
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aKazanietz, Marcelo G.
_eeditor.
245 1 0 _aProtein Kinase C in Cancer Signaling and Therapy
_h[electronic resource] /
_cedited by Marcelo G. Kazanietz.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana Press,
_c2010.
300 _aXIV, 494p. 37 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Cancer Research
505 0 _aRegulation of PKC Isozyme Function: From Genes to Biochemistry -- Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective -- Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids -- Phorbol Esters and Diacylglycerol: The PKC Activators -- Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals -- Regulation of PKC by Protein–Protein Interactions in Cancer -- PKC Isozymes in the Control of Cell Function -- Introduction: PKC Isozymes in the Control of Cell Function -- Regulation and Function of Protein Kinase D Signaling -- PKC and Control of the Cell Cycle -- PKC and the Control of Apoptosis -- Atypical PKCs, NF-?B, and Inflammation -- PKC Isozymes in Cancer -- Introduction: PKC and Cancer -- Protein Kinase C, p53, and DNA Damage -- PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways -- PKC–PKD Interplay in Cancer -- Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer -- PKC Isozymes and Skin Cancer -- PKC and Breast Cancer -- PKC and Prostate Cancer -- Protein Kinase C and Lung Cancer -- PKC Isozymes as Targets for Cancer Therapy -- PKC and Resistance to Chemotherapeutic Agents -- PKC? as a Target for Chemotherapeutic Drugs -- Atypical PKCs as Targets for Cancer Therapy.
520 _aProtein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. It is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. Protein Kinase C in Cancer Signaling and Therapy is composed of twenty-three chapters written by leading experts in the field. The book is divided into four sections: Regulation of PKC isozyme function: from genes to biochemistry, PKC isozymes in the control of cell function, PKC isozymes in cancer, and PKC isozymes as targets for cancer therapy. Each section of Protein Kinase C in Cancer Signaling and Therapy begins with an introduction by an established professional in the field of Protein kinase C, followed by chapters that elucidate the importance of PKC in current cancer research.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781607615422
830 0 _aCurrent Cancer Research
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-60761-543-9
912 _aZDB-2-SME
999 _c110823
_d110823