000 04005nam a22004575i 4500
001 978-1-60761-451-7
003 DE-He213
005 20140220084513.0
007 cr nn 008mamaa
008 100301s2010 xxu| s |||| 0|eng d
020 _a9781607614517
_9978-1-60761-451-7
024 7 _a10.1007/978-1-60761-451-7
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aPenichet, Manuel L.
_eeditor.
245 1 0 _aCancer and IgE
_h[electronic resource] :
_bIntroducing the Concept of AllergoOncology /
_cedited by Manuel L. Penichet, Erika Jensen-Jarolim.
264 1 _aTotowa, NJ :
_bHumana Press,
_c2010.
300 _aIX, 280p. 31 illus., 21 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aThe Biology of IgE: Molecular Mechanism Restraining Potentially Dangerous High Serum IgE Titres In Vivo -- The Biology of IgE: The Generation of High-Affinity IgE Antibodies -- Epidemiological Evidence: IgE, Atopy, and Solid Tumors -- Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies -- Mast Cells in Allergy and Tumor Disease -- The IgE Antibody and Its Use in Cancer Immunotherapy -- IgE Interacts with Potent Effector Cells Against Tumors: ADCC and ADCP -- IgE as Adjuvant in Tumor Vaccination -- The Targets of IgE: Allergen-Associated and Tumor-Associated Molecular Patterns -- The Role of Th2-Mediated Anti-Tumor Immunity in Tumor Surveillance and Clearance.
520 _aAllergies are caused by a person’s own IgE antibodies directed against innocuous antigens like pollen or house dust mites. Interestingly, several studies have examined the relation between allergies or level of IgE and malignancies and have found an inverse association suggesting a natural role of IgE in cancer immunosurveillance. Is it thus possible that IgE immunoglobulins could have a beneficial function against cancer besides their harmful function in allergy? If so, can we exploit this beneficial function for the development of new cancer therapies? Could oncologists learn from allergists and vice versa? This book attempts to explore step by step these interesting questions, opening a novel science field: AllergoOncology. AllergoOncology by definition aims to reveal the function of IgE-mediated immune responses against cancer cells in order to enhance the understanding of its biology and to develop novel IgE-based treatment options against malignant diseases. Cancer and IgE: Introducing the Concept of AllergoOncology opens new avenues towards IgE antibodies as key effector molecules able to confer protection against cancer development and progression. This affinity-matured class of antibody, belonging to Th2-mediated immunity, uses an exquisite panel of potent effector cells which can eradicate malignant cells. Importantly, IgE is also capable of binding to professional antigen presenting cells thereby enhancing the presentation of cancer antigens and leading to a significant anti-tumor immune response. Based on its anti-tumor efficacy, which has been shown in vitro and in preclinical models, IgE can be potentially used in human in the context passive and active cancer immunotherapy. In summary, this book, which is the first of its class, is a comprehensive volume about the evolving new field AllergoOncology.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aImmunology.
650 2 4 _aOncology.
700 1 _aJensen-Jarolim, Erika.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781607614500
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-60761-451-7
912 _aZDB-2-SBL
999 _c110816
_d110816