000 02645nam a22004455i 4500
001 978-1-4419-8231-5
003 DE-He213
005 20140220084512.0
007 cr nn 008mamaa
008 110713s2010 xxu| s |||| 0|eng d
020 _a9781441982315
_9978-1-4419-8231-5
024 7 _a10.1007/978-1-4419-8231-5
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aAyed, Ayeda.
_eauthor.
245 1 0 _ap53
_h[electronic resource] /
_cby Ayeda Ayed, Theodore Hupp.
264 1 _aBoston, MA :
_bSpringer US :
_bImprint: Springer,
_c2010.
300 _aXVI, 200p. 59 illus., 3 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMolecular Biology Intelligence Unit,
_x1431-0414 ;
_v1
505 0 _aTP53 Mutations in Human Cancers: Selection versus Mutagenesis -- Lessons on p53 from Mouse Models -- TP63, TP73: The Guardian’s Elder Brothers -- The Regulation of p53 Protein Function by Phosphorylation -- The p53-Mdm2 Loop: A Critical Juncture of Stress Response -- Cooperation between MDM2 and MDMX in the Regulation of p53 -- Regulation and Function of the Original p53- Inducible p21 Gene -- p53 Localization -- Modes of p53 Interactions with DNA in the Chromatin Context -- p53’s Dilemma in Transcription: Analysis by Microarrays -- Tumor Viruses and p53 -- p53 and Immunity.
520 _aThis volume, p53, was developed primarily as a resource for access to key ideas in the field that have developed over the years including how transgenics have been used to study p53, how clinical genetics have identified and studied mutations in p53 found in human cancers, how p53 can be regulated by post-translational modification, and how key drug targets have been defined, namely MDM2, which has provided fundamental approaches for defining how p53 can be activated with potentially therapeutic effect. The key concepts in the chapters included provide a perspective on key paradigms in the p53 field.
650 0 _aMedicine.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
700 1 _aHupp, Theodore.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781441982308
830 0 _aMolecular Biology Intelligence Unit,
_x1431-0414 ;
_v1
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4419-8231-5
912 _aZDB-2-SBL
999 _c110759
_d110759